MESP1
Gene Information
- Official Symbol: MESP1
- Official Name: mesoderm posterior bHLH transcription factor 1
- Aliases and Previous Symbols: N/A
- Entrez ID: 55897
- UniProt: Q9BRJ9
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: Transcription factor. Plays a role in the epithelialization of somitic mesoderm and in the development of cardiac mesoderm. Defines the rostrocaudal patterning of the somites by participating in distinct Notch pathways (By similarity). {ECO:0000250}.
Pfam Domains GO Terms
Pfam Domains
| HLH |
GO Terms
| cardioblast migration |
| sinus venosus development |
| cardioblast migration to the midline involved in heart field formation |
| sinus venosus morphogenesis |
| positive regulation of hepatocyte differentiation |
| cell migration to the midline involved in heart development |
| cardioblast anterior-lateral migration |
| negative regulation of endodermal cell fate specification |
| cardiac atrium formation |
| regulation of heart induction by regulation of canonical Wnt signaling pathway |
| regulation of hepatocyte differentiation |
| regulation of endodermal cell fate specification |
| positive regulation of heart induction by negative regulation of canonical Wnt signaling pathway |
| cell migration involved in heart formation |
| sinoatrial node development |
| negative regulation of endodermal cell differentiation |
| sinoatrial node cell differentiation |
| cardiac cell fate determination |
| regulation of endodermal cell differentiation |
| negative regulation of mesodermal cell fate specification |
| growth involved in heart morphogenesis |
| negative regulation of mesoderm formation |
| negative regulation of mesodermal cell differentiation |
| regulation of Notch signaling pathway involved in heart induction |
| positive regulation of Notch signaling pathway involved in heart induction |
| cardiac pacemaker cell differentiation |
| negative regulation of Wnt signaling pathway involved in heart development |
| mesodermal cell migration |
| positive regulation of heart induction |
| regulation of heart induction |
| negative regulation of cell fate specification |
| convergent extension involved in organogenesis |
| regulation of Wnt signaling pathway involved in heart development |
| cardiac vascular smooth muscle cell differentiation |
| regulation of mesoderm formation |
| negative regulation of gastrulation |
| regulation of mesodermal cell differentiation |
| regulation of mesodermal cell fate specification |
| negative regulation of mesoderm development |
| heart field specification |
| secondary heart field specification |
| cardiac cell fate commitment |
| cardiac ventricle formation |
| cardiac chamber formation |
| cardiac conduction system development |
| lateral mesoderm development |
| regulation of cell fate specification |
| heart formation |
| negative regulation of cell fate commitment |
| cell migration involved in heart development |
| convergent extension |
| vascular smooth muscle cell differentiation |
| enhancer binding |
| specification of animal organ identity |
| regulation of mesoderm development |
| signal transduction involved in regulation of gene expression |
| negative regulation of embryonic development |
| heart growth |
| regulation of cell fate commitment |
| cardiac atrium morphogenesis |
| smooth muscle cell differentiation |
| animal organ formation |
| cardiac atrium development |
| regulation of animal organ formation |
| regulation of gastrulation |
| cell fate determination |
| regulation of heart morphogenesis |
| coronary vasculature development |
| positive regulation of Notch signaling pathway |
| positive regulation of striated muscle cell differentiation |
| positive regulation of epithelial cell differentiation |
| heart looping |
| somitogenesis |
| embryonic heart tube morphogenesis |
| determination of heart left/right asymmetry |
| mesoderm formation |
| mesoderm morphogenesis |
| cardiac ventricle morphogenesis |
| embryonic heart tube development |
| positive regulation of animal organ morphogenesis |
| endothelial cell differentiation |
| somite development |
| positive regulation of muscle cell differentiation |
| cardiac muscle cell differentiation |
| endothelium development |
| segmentation |
| organ growth |
| regulation of striated muscle cell differentiation |
| regulation of Notch signaling pathway |
| formation of primary germ layer |
| developmental growth involved in morphogenesis |
| cardiocyte differentiation |
| determination of left/right symmetry |
| determination of bilateral symmetry |
| mesoderm development |
| specification of symmetry |
| Notch signaling pathway |
| cardiac chamber morphogenesis |
| cardiac ventricle development |
| regulation of embryonic development |
| regulation of epithelial cell differentiation |
| regulation of muscle cell differentiation |
| gastrulation |
| protein dimerization activity |
| cardiac muscle tissue development |
| cardiac chamber development |
| ameboidal-type cell migration |
| negative regulation of canonical Wnt signaling pathway |
| striated muscle cell differentiation |
| negative regulation of Wnt signaling pathway |
| anterior/posterior pattern specification |
| transcription regulatory region DNA binding |
| mesenchyme development |
| muscle cell differentiation |
| cell fate commitment |
| heart morphogenesis |
| regulation of animal organ morphogenesis |
| regulation of canonical Wnt signaling pathway |
| striated muscle tissue development |
| embryonic organ morphogenesis |
| muscle tissue development |
| epithelial tube morphogenesis |
| regionalization |
| regulation of Wnt signaling pathway |
| developmental growth |
| growth |
| morphogenesis of an epithelium |
| embryonic organ development |
| pattern specification process |
| DNA-binding transcription activator activity, RNA polymerase II-specific |
| muscle structure development |
| blood vessel development |
| RNA polymerase II proximal promoter sequence-specific DNA binding |
| vasculature development |
| cardiovascular system development |
| heart development |
| tissue morphogenesis |
| embryonic morphogenesis |
| chordate embryonic development |
| embryo development ending in birth or egg hatching |
| tube morphogenesis |
| DNA-binding transcription factor activity |
| epithelial cell differentiation |
| negative regulation of cell differentiation |
| tube development |
| circulatory system development |
| anatomical structure formation involved in morphogenesis |
| negative regulation of developmental process |
| animal organ morphogenesis |
| cell migration |
| positive regulation of cell differentiation |
| embryo development |
| regulation of anatomical structure morphogenesis |
| cell motility |
| localization of cell |
| epithelium development |
| negative regulation of transcription, DNA-templated |
| negative regulation of multicellular organismal process |
| positive regulation of transcription by RNA polymerase II |
| negative regulation of nucleic acid-templated transcription |
| negative regulation of RNA biosynthetic process |
| negative regulation of signal transduction |
| locomotion |
| negative regulation of RNA metabolic process |
| negative regulation of cell communication |
| negative regulation of signaling |
| positive regulation of developmental process |
| negative regulation of cellular macromolecule biosynthetic process |
| negative regulation of nucleobase-containing compound metabolic process |
| negative regulation of macromolecule biosynthetic process |
| negative regulation of cellular biosynthetic process |
| positive regulation of transcription, DNA-templated |
| negative regulation of biosynthetic process |
| movement of cell or subcellular component |
| DNA-binding transcription factor activity, RNA polymerase II-specific |
| negative regulation of response to stimulus |
| neurogenesis |
| positive regulation of nucleic acid-templated transcription |
| positive regulation of RNA biosynthetic process |
| positive regulation of signal transduction |
| negative regulation of gene expression |
| positive regulation of RNA metabolic process |
| positive regulation of multicellular organismal process |
| tissue development |
| regulation of cell differentiation |
| positive regulation of cell communication |
| positive regulation of signaling |
| positive regulation of nucleobase-containing compound metabolic process |
| positive regulation of macromolecule biosynthetic process |
| positive regulation of cellular biosynthetic process |
| positive regulation of gene expression |
| positive regulation of biosynthetic process |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
| Screen | Score |
|---|---|
| Hippuristanol 0.12μM R08 exp489 no dilution day6 | 1.73 |
| Etoposide 0.3μM R05 exp199 | 1.86 |
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 8783
- Expression level (log2 read counts): -1.14
Expression Distribution
MESP1 Expression in NALM6 Cells: -1.14
