METRN

Entrez Summary: N/A
UniProt Summary: Involved in both glial cell differentiation and axonal network formation during neurogenesis. Promotes astrocyte differentiation and transforms cerebellar astrocytes into radial glia. Also induces axonal extension in small and intermediate neurons of sensory ganglia by activating nearby satellite glia (By similarity). {ECO:0000250}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

positive regulation of axonogenesis
hormone activity
positive regulation of cell morphogenesis involved in differentiation
glial cell differentiation
regulation of axonogenesis
gliogenesis
positive regulation of neuron projection development
regulation of cell morphogenesis involved in differentiation
positive regulation of neuron differentiation
positive regulation of cell projection organization
positive regulation of neurogenesis
regulation of cell morphogenesis
regulation of neuron projection development
positive regulation of nervous system development
positive regulation of cell development
regulation of neuron differentiation
regulation of plasma membrane bounded cell projection organization
regulation of cell projection organization
regulation of neurogenesis
regulation of nervous system development
regulation of cell development
positive regulation of cell differentiation
regulation of anatomical structure morphogenesis
positive regulation of cellular component organization
positive regulation of developmental process
generation of neurons
extracellular space
neurogenesis
positive regulation of multicellular organismal process
regulation of cell differentiation