METTL21C [The Human Chemical-Genetic Interaction Map Project]

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======= METTL21C =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: METTL21C
  * **<color #00a2e8>Official Name</color>**: methyltransferase like 21C
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=196541|196541]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q5VZV1|Q5VZV1]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=METTL21C&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20METTL21C|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/615259|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Protein-lysine methyltransferase. {ECO:0000269|PubMed:22948820}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Methyltransf 16|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|hormone-mediated apoptotic signaling pathway|
|protein-lysine N-methyltransferase activity|
|regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|
|cellular response to dexamethasone stimulus|
|response to dexamethasone|
|cellular response to glucocorticoid stimulus|
|heat shock protein binding|
|cellular response to corticosteroid stimulus|
|regulation of release of sequestered calcium ion into cytosol|
|peptidyl-lysine methylation|
|cellular response to ketone|
|response to antineoplastic agent|
|regulation of calcium ion transport into cytosol|
|skeletal muscle tissue development|
|regulation of sequestering of calcium ion|
|skeletal muscle organ development|
|protein alkylation|
|protein methylation|
|response to glucocorticoid|
|regulation of calcium ion transmembrane transport|
|response to corticosteroid|
|hormone-mediated signaling pathway|
|cellular response to xenobiotic stimulus|
|cellular response to steroid hormone stimulus|
|response to ketone|
|regulation of calcium ion transport|
|macromolecule methylation|
|apoptotic signaling pathway|
|striated muscle tissue development|
|muscle organ development|
|muscle tissue development|
|response to xenobiotic stimulus|
|methylation|
|peptidyl-lysine modification|
|response to steroid hormone|
|regulation of cation transmembrane transport|
|regulation of metal ion transport|
|cellular response to drug|
|muscle structure development|
|regulation of ion transmembrane transport|
|cellular response to lipid|
|cellular response to organic cyclic compound|
|regulation of transmembrane transport|
|protein-containing complex|
|cellular response to hormone stimulus|
|regulation of ion transport|
|response to lipid|
|peptidyl-amino acid modification|
|response to hormone|
|regulation of cellular localization|
|response to organic cyclic compound|
|apoptotic process|
|response to drug|
|programmed cell death|
|cellular response to oxygen-containing compound|
|cell death|
|cellular response to endogenous stimulus|
|response to endogenous stimulus|
|response to oxygen-containing compound|
|tissue development|
|regulation of transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp46|HMS-I1 1μM R01 exp46]]|-2.12|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 14103
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -6.6 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='METTL21C Expression in NALM6 Cells: -6.6'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>