MFHAS1

Gene Information

Official Symbol: MFHAS1
Official Name: malignant fibrous histiocytoma amplified sequence 1
Aliases and Previous Symbols: N/A
Entrez ID: 9258
UniProt: Q9Y4C4
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: Identified in a human 8p amplicon, this gene is a potential oncogene whose expression is enhanced in some malignant fibrous histiocytomas (MFH). The primary structure of its product includes an ATP/GTP-binding site, three leucine zipper domains, and a leucine-rich tandem repeat, which are structural or functional elements for interactions among proteins related to the cell cycle, and which suggest that overexpression might be oncogenic with respect to MFH. [provided by RefSeq, Jul 2008].
UniProt Summary: N/A

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 5054
Expression level (log2 read counts): 6.61

Expression Distribution

negative regulation of toll-like receptor 2 signaling pathway
positive regulation of toll-like receptor 2 signaling pathway
negative regulation of toll-like receptor 4 signaling pathway
regulation of toll-like receptor 2 signaling pathway
regulation of toll-like receptor 4 signaling pathway
positive regulation of toll-like receptor signaling pathway
positive regulation of p38MAPK cascade
negative regulation of protein localization to nucleus
protein phosphatase 2A binding
negative regulation of toll-like receptor signaling pathway
regulation of p38MAPK cascade
regulation of macrophage activation
negative regulation of protein dephosphorylation
regulation of toll-like receptor signaling pathway
erythrocyte differentiation
erythrocyte homeostasis
myeloid cell homeostasis
negative regulation of dephosphorylation
negative regulation of cellular protein localization
regulation of protein localization to nucleus
negative regulation of inflammatory response
positive regulation of JNK cascade
regulation of protein dephosphorylation
positive regulation of protein kinase B signaling
positive regulation of stress-activated MAPK cascade
positive regulation of stress-activated protein kinase signaling cascade
regulation of JNK cascade
homeostasis of number of cells
negative regulation of defense response
positive regulation of ERK1 and ERK2 cascade
regulation of dephosphorylation
regulation of protein kinase B signaling
myeloid cell differentiation
regulation of stress-activated MAPK cascade
regulation of stress-activated protein kinase signaling cascade
lysosome
ubiquitin protein ligase binding
regulation of ERK1 and ERK2 cascade
regulation of inflammatory response
positive regulation of innate immune response