MGARP [The Human Chemical-Genetic Interaction Map Project]

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======= MGARP =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: MGARP
  * **<color #00a2e8>Official Name</color>**: mitochondria localized glutamic acid rich protein
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=84709|84709]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q8TDB4|Q8TDB4]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=MGARP&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20MGARP|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/619684|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Plays a role in the trafficking of mitochondria along microtubules. Regulates the kinesin-mediated axonal transport of mitochondria to nerve terminals along microtubules during hypoxia. Participates in the translocation of TRAK2/GRIF1 from the cytoplasm to the mitochondrion. Also plays a role in steroidogenesis through maintenance of mitochondrial abundance and morphology (By similarity). {ECO:0000250}.

<button type='default' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
No Pfam Domain information is available for this gene.
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|cellular response to gonadotropin-releasing hormone|
|response to gonadotropin-releasing hormone|
|axonal transport of mitochondrion|
|retrograde axonal transport|
|integral component of mitochondrial outer membrane|
|establishment of mitochondrion localization, microtubule-mediated|
|mitochondrion transport along microtubule|
|establishment of mitochondrion localization|
|anterograde axonal transport|
|mitochondrion localization|
|axonal transport|
|axon cytoplasm|
|protein targeting to mitochondrion|
|axo-dendritic transport|
|establishment of protein localization to mitochondrion|
|protein localization to mitochondrion|
|organelle transport along microtubule|
|positive regulation of mitochondrion organization|
|transport along microtubule|
|cytoskeleton-dependent intracellular transport|
|regulation of mitochondrion organization|
|microtubule-based transport|
|cellular response to steroid hormone stimulus|
|cellular response to hypoxia|
|cellular response to decreased oxygen levels|
|mitochondrial transport|
|cellular response to oxygen levels|
|cellular response to peptide hormone stimulus|
|microtubule-based movement|
|cellular response to peptide|
|response to steroid hormone|
|response to hypoxia|
|response to decreased oxygen levels|
|protein targeting|
|establishment of organelle localization|
|response to oxygen levels|
|response to peptide hormone|
|establishment of protein localization to organelle|
|mitochondrion organization|
|response to peptide|
|cellular response to lipid|
|cellular response to organic cyclic compound|
|organelle localization|
|cellular response to organonitrogen compound|
|cellular response to hormone stimulus|
|positive regulation of organelle organization|
|cellular response to nitrogen compound|
|microtubule-based process|
|protein localization to organelle|
|response to lipid|
|response to hormone|
|response to organic cyclic compound|
|intracellular protein transport|
|response to organonitrogen compound|
|cellular response to oxygen-containing compound|
|response to nitrogen compound|
|response to abiotic stimulus|
|positive regulation of cellular component organization|
|cellular response to endogenous stimulus|
|mitochondrion|
|regulation of organelle organization|
|response to endogenous stimulus|
|protein transport|
|intracellular transport|
|peptide transport|
|movement of cell or subcellular component|
|response to oxygen-containing compound|
|amide transport|
|cellular protein localization|
|cellular macromolecule localization|
|establishment of protein localization|
|cellular response to stress|
|establishment of localization in cell|
|nitrogen compound transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp345|Cidofovir 10μM R07 exp345]]|-1.82|
|[[:results:exp31|Rifampicin 1μM R00 exp31]]|2.04|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 18463
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -2.96 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='MGARP Expression in NALM6 Cells: -2.96'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>