MGARP

Entrez Summary: N/A
UniProt Summary: Plays a role in the trafficking of mitochondria along microtubules. Regulates the kinesin-mediated axonal transport of mitochondria to nerve terminals along microtubules during hypoxia. Participates in the translocation of TRAK2/GRIF1 from the cytoplasm to the mitochondrion. Also plays a role in steroidogenesis through maintenance of mitochondrial abundance and morphology (By similarity). {ECO:0000250}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Screen	Score
Cidofovir 10μM R07 exp345	-1.82
Rifampicin 1μM R00 exp31	2.04

cellular response to gonadotropin-releasing hormone
response to gonadotropin-releasing hormone
axonal transport of mitochondrion
retrograde axonal transport
integral component of mitochondrial outer membrane
establishment of mitochondrion localization, microtubule-mediated
mitochondrion transport along microtubule
establishment of mitochondrion localization
anterograde axonal transport
mitochondrion localization
axonal transport
axon cytoplasm
protein targeting to mitochondrion
axo-dendritic transport
establishment of protein localization to mitochondrion
protein localization to mitochondrion
organelle transport along microtubule
positive regulation of mitochondrion organization
transport along microtubule
cytoskeleton-dependent intracellular transport
regulation of mitochondrion organization
microtubule-based transport
cellular response to steroid hormone stimulus
cellular response to hypoxia
cellular response to decreased oxygen levels
mitochondrial transport
cellular response to oxygen levels
cellular response to peptide hormone stimulus
microtubule-based movement
cellular response to peptide
response to steroid hormone
response to hypoxia
response to decreased oxygen levels
protein targeting
establishment of organelle localization
response to oxygen levels
response to peptide hormone
establishment of protein localization to organelle
mitochondrion organization
response to peptide