MGAT3

Gene Information

Official Symbol: MGAT3
Official Name: beta-1,4-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase
Aliases and Previous Symbols: N/A
Entrez ID: 4248
UniProt: Q09327
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: It is involved in the regulation of the biosynthesis and biological function of glycoprotein oligosaccharides. Catalyzes the addition of N-acetylglucosamine in beta 1-4 linkage to the beta-linked mannose of the trimannosyl core of N-linked sugar chains. It is one of the most important enzymes involved in the regulation of the biosynthesis of glycoprotein oligosaccharides.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 3295
Expression level (log2 read counts): -0.32

Expression Distribution

Screen	Score
MLN-4924 2μM R00 exp22	-1.94
CCCP 0.1μM R00 exp10	-1.76
Q15 1 to 2μM on day4 R04 exp164	1.8

beta-1,4-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity
negative regulation of lysosomal protein catabolic process
negative regulation of protein catabolic process in the vacuole
positive regulation of protein localization to early endosome
regulation of protein localization to early endosome
regulation of lysosomal protein catabolic process
regulation of protein catabolic process in the vacuole
positive regulation of protein localization to endosome
regulation of protein localization to endosome
transferase activity, transferring glycosyl groups
N-acetylglucosamine metabolic process
amyloid-beta metabolic process
glucosamine-containing compound metabolic process
amino sugar metabolic process
protein N-linked glycosylation
negative regulation of cellular protein catabolic process
negative regulation of protein catabolic process
cellular response to oxidative stress
regulation of cellular protein catabolic process
negative regulation of cellular catabolic process
protein glycosylation
macromolecule glycosylation
glycosylation
cognition
negative regulation of catabolic process
glycoprotein biosynthetic process
positive regulation of cellular protein localization
regulation of protein catabolic process
glycoprotein metabolic process
response to oxidative stress
peptide metabolic process
regulation of cellular protein localization
Golgi membrane
carbohydrate derivative biosynthetic process
cellular amide metabolic process
regulation of cellular catabolic process
regulation of cell migration
regulation of cell motility
regulation of cellular localization
regulation of locomotion