MGLL

Entrez Summary: N/A
UniProt Summary: Converts monoacylglycerides to free fatty acids and glycerol. Hydrolyzes the endocannabinoid 2-arachidonoylglycerol, and thereby contributes to the regulation of endocannabinoid signaling, nociperception and perception of pain (By similarity). Regulates the levels of fatty acids that serve as signaling molecules and promote cancer cell migration, invasion and tumor growth (PubMed:20079333). {ECO:0000250|UniProtKB:O35678, ECO:0000269|PubMed:20079333}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

regulation of endocannabinoid signaling pathway
monoacylglycerol metabolic process
monoacylglycerol catabolic process
acylglycerol acyl-chain remodeling
acylglycerol lipase activity
lysophospholipase activity
triglyceride catabolic process
neutral lipid catabolic process
acylglycerol catabolic process
regulation of sensory perception of pain
regulation of sensory perception
glycerolipid catabolic process
arachidonic acid metabolic process
extrinsic component of membrane
triglyceride metabolic process
acylglycerol metabolic process
neutral lipid metabolic process
unsaturated fatty acid metabolic process
icosanoid metabolic process
long-chain fatty acid metabolic process
fatty acid biosynthetic process
regulation of nervous system process
regulation of G protein-coupled receptor signaling pathway
fatty acid derivative metabolic process
monocarboxylic acid biosynthetic process
cellular lipid catabolic process
lipid catabolic process
carboxylic acid biosynthetic process
organic acid biosynthetic process
fatty acid metabolic process
regulation of inflammatory response
glycerolipid metabolic process
inflammatory response
monocarboxylic acid metabolic process
lipid biosynthetic process
regulation of system process
small molecule biosynthetic process
regulation of defense response
protein homodimerization activity
carboxylic acid metabolic process