MGRN1

Entrez Summary: N/A
UniProt Summary: E3 ubiquitin-protein ligase. Mediates monoubiquitination at multiple sites of TSG101 in the presence of UBE2D1, but not of UBE2G1, nor UBE2H. Plays a role in the regulation of endosome-to- lysosome trafficking. Impairs MC1R- and MC4R-signaling by competing with GNAS-binding to MCRs and inhibiting agonist-induced cAMP production. Does not inhibit ADRB2-signaling. Does not promote MC1R ubiquitination. {ECO:0000269|PubMed:17229889, ECO:0000269|PubMed:19703557, ECO:0000269|PubMed:19737927}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

negative regulation of cAMP-mediated signaling
negative regulation of smoothened signaling pathway
negative regulation of G protein-coupled receptor signaling pathway
regulation of cAMP-mediated signaling
endosome to lysosome transport
protein monoubiquitination
regulation of smoothened signaling pathway
lysosomal transport
vacuolar transport
regulation of G protein-coupled receptor signaling pathway
ubiquitin protein ligase activity
ubiquitin-protein transferase activity
early endosome
protein polyubiquitination
negative regulation of intracellular signal transduction
protein ubiquitination
protein modification by small protein conjugation
protein modification by small protein conjugation or removal
negative regulation of signal transduction
negative regulation of cell communication
negative regulation of signaling
intracellular transport
negative regulation of response to stimulus
regulation of intracellular signal transduction
establishment of localization in cell
vesicle-mediated transport
membrane