MIB1

• Official Symbol: MIB1
• Official Name: mindbomb E3 ubiquitin protein ligase 1
• Aliases and Previous Symbols: N/A
• Entrez ID: 57534
• UniProt: Q86YT6
• Interactions: BioGRID
• PubMed articles: Open PubMed
• OMIM: Open OMIM

• Entrez Summary: This gene encodes a protein containing multiple ankyrin repeats and RING finger domains that functions as an E3 ubiquitin ligase. The encoded protein positively regulates Notch signaling by ubiquitinating the Notch receptors, thereby facilitating their endocytosis. This protein may also promote the ubiquitination and degradation of death-associated protein kinase 1 (DAPK1). [provided by RefSeq, Jun 2013].
• UniProt Summary: N/A

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

• Essentiality Rank: 16468
• Expression level (log2 read counts): 6.61

Expression Distribution

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MIB1 Expression in NALM6 Cells: 6.61