MID1IP1 [The Human Chemical-Genetic Interaction Map Project]

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======= MID1IP1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: MID1IP1
  * **<color #00a2e8>Official Name</color>**: MID1 interacting protein 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=58526|58526]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9NPA3|Q9NPA3]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=MID1IP1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20MID1IP1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/300961|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Plays a role in the regulation of lipogenesis in liver. Up-regulates ACACA enzyme activity. Required for efficient lipid biosynthesis, including triacylglycerol, diacylglycerol and phospholipid. Involved in stabilization of microtubules (By similarity). {ECO:0000250}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Spot 14|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|positive regulation of ligase activity|
|regulation of ligase activity|
|carnitine shuttle|
|fatty acid transmembrane transport|
|positive regulation of fatty acid biosynthetic process|
|negative regulation of microtubule depolymerization|
|regulation of microtubule depolymerization|
|positive regulation of fatty acid metabolic process|
|intracellular lipid transport|
|negative regulation of microtubule polymerization or depolymerization|
|regulation of fatty acid biosynthetic process|
|long-chain fatty acid transport|
|negative regulation of protein depolymerization|
|negative regulation of protein complex disassembly|
|fatty acid transport|
|positive regulation of lipid biosynthetic process|
|regulation of microtubule polymerization or depolymerization|
|regulation of protein depolymerization|
|protein polymerization|
|regulation of fatty acid metabolic process|
|mitochondrial transmembrane transport|
|regulation of protein complex disassembly|
|carboxylic acid transmembrane transport|
|organic acid transmembrane transport|
|negative regulation of supramolecular fiber organization|
|monocarboxylic acid transport|
|positive regulation of small molecule metabolic process|
|negative regulation of cytoskeleton organization|
|positive regulation of lipid metabolic process|
|microtubule cytoskeleton|
|regulation of cellular ketone metabolic process|
|regulation of lipid biosynthetic process|
|regulation of microtubule cytoskeleton organization|
|protein C-terminus binding|
|mitochondrial transport|
|regulation of microtubule-based process|
|anion transmembrane transport|
|organic acid transport|
|carboxylic acid transport|
|lipid transport|
|microtubule|
|lipid localization|
|regulation of supramolecular fiber organization|
|negative regulation of organelle organization|
|regulation of lipid metabolic process|
|regulation of small molecule metabolic process|
|organic anion transport|
|regulation of cytoskeleton organization|
|anion transport|
|negative regulation of cellular component organization|
|cellular protein-containing complex assembly|
|ion transmembrane transport|
|identical protein binding|
|lipid metabolic process|
|transmembrane transport|
|regulation of organelle organization|
|ion transport|
|positive regulation of catalytic activity|
|intracellular transport|
|protein-containing complex assembly|
|positive regulation of molecular function|
|establishment of localization in cell|
|protein-containing complex subunit organization|
|positive regulation of cellular biosynthetic process|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp463|Caffeine 2600μM R08 exp463]]|-2.2|
|[[:results:exp34|Rotenone 20μM R00 exp34]]|-1.96|
|[[:results:exp48|Mubritinib 0.2μM R01 exp48]]|-1.93|
|[[:results:exp416|Tubacin 1.6μM R07 exp416]]|1.79|
|[[:results:exp226|Cerivastatin 0.15μM R05 exp226]]|1.82|
|[[:results:exp220|BAY-598 4μM R05 exp220]]|1.84|
|[[:results:exp84|UM0125461 0.74μM R02 exp84]]|2.35|
|[[:results:exp79|Q15 2.7μM R02 exp79]]|2.37|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:a:acaca|ACACA]]|0.485|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/694
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/26|
|bone|0/26|
|breast|0/30|
|central nervous system|0/49|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/11|
|fibroblast|0/1|
|gastric|0/14|
|kidney|0/18|
|liver|0/19|
|lung|0/72|
|lymphocyte|0/16|
|ovary|0/25|
|pancreas|0/22|
|peripheral nervous system|0/15|
|plasma cell|0/12|
|prostate|0/1|
|skin|0/20|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/28|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 15263
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.52 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='MID1IP1 Expression in NALM6 Cells: 6.52'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>