MID1IP1

Gene Information

Official Symbol: MID1IP1
Official Name: MID1 interacting protein 1
Aliases and Previous Symbols: N/A
Entrez ID: 58526
UniProt: Q9NPA3
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: Plays a role in the regulation of lipogenesis in liver. Up-regulates ACACA enzyme activity. Required for efficient lipid biosynthesis, including triacylglycerol, diacylglycerol and phospholipid. Involved in stabilization of microtubules (By similarity). {ECO:0000250}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Caffeine 2600μM R08 exp463	-2.2
Rotenone 20μM R00 exp34	-1.96
Mubritinib 0.2μM R01 exp48	-1.93
Tubacin 1.6μM R07 exp416	1.79
Cerivastatin 0.15μM R05 exp226	1.82
BAY-598 4μM R05 exp220	1.84
UM0125461 0.74μM R02 exp84	2.35
Q15 2.7μM R02 exp79	2.37

Global Fraction of Cell Lines Where Essential: 0/694

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/26
bone	0/26
breast	0/30
central nervous system	0/49
cervix	0/4
colorectal	0/17
esophagus	0/11
fibroblast	0/1
gastric	0/14
kidney	0/18
liver	0/19
lung	0/72
lymphocyte	0/16
ovary	0/25
pancreas	0/22
peripheral nervous system	0/15
plasma cell	0/12
prostate	0/1
skin	0/20
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/28
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 15263
Expression level (log2 read counts): 6.52

Expression Distribution

positive regulation of ligase activity
regulation of ligase activity
carnitine shuttle
fatty acid transmembrane transport
positive regulation of fatty acid biosynthetic process
negative regulation of microtubule depolymerization
regulation of microtubule depolymerization
positive regulation of fatty acid metabolic process
intracellular lipid transport
negative regulation of microtubule polymerization or depolymerization
regulation of fatty acid biosynthetic process
long-chain fatty acid transport
negative regulation of protein depolymerization
negative regulation of protein complex disassembly
fatty acid transport
positive regulation of lipid biosynthetic process
regulation of microtubule polymerization or depolymerization
regulation of protein depolymerization
protein polymerization
regulation of fatty acid metabolic process
mitochondrial transmembrane transport
regulation of protein complex disassembly
carboxylic acid transmembrane transport
organic acid transmembrane transport
negative regulation of supramolecular fiber organization
monocarboxylic acid transport
positive regulation of small molecule metabolic process
negative regulation of cytoskeleton organization
positive regulation of lipid metabolic process
microtubule cytoskeleton
regulation of cellular ketone metabolic process
regulation of lipid biosynthetic process
regulation of microtubule cytoskeleton organization
protein C-terminus binding
mitochondrial transport
regulation of microtubule-based process
anion transmembrane transport
organic acid transport
carboxylic acid transport
lipid transport