MID2

Gene Information

Official Symbol: MID2
Official Name: midline 2
Aliases and Previous Symbols: N/A
Entrez ID: 11043
UniProt: Q9UJV3
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. The protein localizes to microtubular structures in the cytoplasm. Alternate splicing of this gene results in two transcript variants encoding different isoforms. [provided by RefSeq, Feb 2009].
UniProt Summary: May play a role in microtubule stabilization. {ECO:0000303|PubMed:24115387}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/694

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/26
bone	0/26
breast	0/30
central nervous system	0/49
cervix	0/4
colorectal	0/17
esophagus	0/11
fibroblast	0/1
gastric	0/14
kidney	0/18
liver	0/19
lung	0/72
lymphocyte	0/16
ovary	0/25
pancreas	0/22
peripheral nervous system	0/15
plasma cell	0/12
prostate	0/1
skin	0/20
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/28
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 11513
Expression level (log2 read counts): -6.6

Expression Distribution

zf-B box
zf-C3HC4
fn3
SPRY

protein localization to microtubule
negative regulation of viral release from host cell
negative regulation of viral entry into host cell
negative regulation of viral transcription
regulation of viral entry into host cell
regulation of viral release from host cell
protein localization to microtubule cytoskeleton
phosphoprotein binding
protein localization to cytoskeleton
transferase activity
regulation of viral transcription
negative regulation of viral life cycle
negative regulation of viral process
positive regulation of autophagy
regulation of viral life cycle
positive regulation of NF-kappaB transcription factor activity
positive regulation of I-kappaB kinase/NF-kappaB signaling
regulation of viral process
negative regulation of multi-organism process
regulation of symbiosis, encompassing mutualism through parasitism
regulation of I-kappaB kinase/NF-kappaB signaling
microtubule binding
positive regulation of DNA-binding transcription factor activity
microtubule
negative regulation of locomotion
regulation of autophagy
positive regulation of cellular catabolic process
regulation of DNA-binding transcription factor activity
positive regulation of catabolic process
protein heterodimerization activity
protein ubiquitination
protein localization to organelle
innate immune response
protein modification by small protein conjugation
regulation of multi-organism process
regulation of cellular catabolic process
zinc ion binding
protein homodimerization activity
defense response to other organism
regulation of locomotion