MIDN [The Human Chemical-Genetic Interaction Map Project]

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======= MIDN =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: MIDN
  * **<color #00a2e8>Official Name</color>**: midnolin
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=90007|90007]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q504T8|Q504T8]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=MIDN&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20MIDN|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/606700|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Facilitates ubiquitin-independent proteasomal degradation of polycomb protein CBX4. Plays a role in inhibiting the activity of glucokinase GCK and both glucose-induced and basal insulin secretion. {ECO:0000250|UniProtKB:D4AE48, ECO:0000250|UniProtKB:Q3TPJ7}.

<button type='default' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
No Pfam Domain information is available for this gene.
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|negative regulation of glucokinase activity|
|negative regulation of hexokinase activity|
|regulation of glucokinase activity|
|regulation of hexokinase activity|
|negative regulation of insulin secretion|
|negative regulation of cellular carbohydrate metabolic process|
|negative regulation of peptide hormone secretion|
|negative regulation of carbohydrate metabolic process|
|negative regulation of hormone secretion|
|kinase binding|
|regulation of glucose metabolic process|
|negative regulation of protein secretion|
|negative regulation of peptide secretion|
|regulation of cellular carbohydrate metabolic process|
|regulation of insulin secretion|
|negative regulation of protein transport|
|negative regulation of establishment of protein localization|
|negative regulation of secretion by cell|
|regulation of carbohydrate metabolic process|
|regulation of peptide hormone secretion|
|negative regulation of secretion|
|negative regulation of kinase activity|
|regulation of hormone secretion|
|negative regulation of transferase activity|
|regulation of small molecule metabolic process|
|negative regulation of phosphorylation|
|regulation of protein secretion|
|negative regulation of transport|
|regulation of peptide secretion|
|regulation of hormone levels|
|negative regulation of phosphate metabolic process|
|negative regulation of phosphorus metabolic process|
|regulation of protein transport|
|regulation of peptide transport|
|regulation of establishment of protein localization|
|regulation of secretion by cell|
|molecular function|
|negative regulation of catalytic activity|
|regulation of secretion|
|nucleolus|
|regulation of kinase activity|
|regulation of transferase activity|
|regulation of protein localization|
|negative regulation of molecular function|
|negative regulation of cell communication|
|negative regulation of signaling|
|regulation of phosphorylation|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|regulation of transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp36|TRAIL 50ng/ml R00 exp36]]|-3.03|
|[[:results:exp89|Vemurafenib 6.6μM R02 exp89]]|-2.52|
|[[:results:exp35|TRAIL 5ng/ml R00 exp35]]|-2.33|
|[[:results:exp79|Q15 2.7μM R02 exp79]]|-2.27|
|[[:results:exp426|FBS-Wisent 0.1 R07 exp426]]|-2.03|
|[[:results:exp434|Vemurafenib 6.6μM R08 exp434]]|-1.98|
|[[:results:exp320|ABT-702 5μM plus CoCl2 18μM R07 exp320]]|-1.85|
|[[:results:exp321|ABT-702 5μM plus Deferoxamine 11μM R07 exp321]]|-1.83|
|[[:results:exp211|AICAR 240μM R05 exp211]]|1.71|
|[[:results:exp478|Doxorubicin 0.02μM R08 exp478]]|1.71|
|[[:results:exp431|Rotenone 0.07μM R08 exp431]]|1.71|
|[[:results:exp374|Latrunculin-B 10μM R07 exp374]]|1.72|
|[[:results:exp466|Cannabidiol 20μM R08 exp466]]|1.73|
|[[:results:exp134|MS023 2μM R03 exp134]]|1.79|
|[[:results:exp456|Benzoate 20000μM R08 exp456]]|1.85|
|[[:results:exp128|GSK591 2.6μM R03 exp128]]|1.87|
|[[:results:exp525|Sulforaphane 9μM R08 exp525]]|1.99|
|[[:results:exp505|ML-792 0.2μM R08 exp505]]|2.04|
|[[:results:exp502|Milciclib 2μM R08 exp502]]|2.52|
|[[:results:exp21|MLN-4924 0.2μM R00 exp21]]|2.55|
|[[:results:exp500|LY2090314 0.003μM R08 exp500 no dilution day6]]|2.67|
|[[:results:exp275|Citral 75μM R06 exp275]]|2.85|
|[[:results:exp499|LY2090314 0.003μM R08 exp499]]|2.86|
|[[:results:exp444|THZ531 0.225μM R08 exp444]]|2.98|
|[[:results:exp190|Vincristine 0.0005μM R04 exp190]]|2.99|
|[[:results:exp524|Staurosporine 0.02μM R08 exp524]]|4.12|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:m:mettl3|METTL3]]|0.444|
|[[:human genes:c:cd19|CD19]]|0.416|
|[[:human genes:m:mapkap1|MAPKAP1]]|0.411|
|[[:human genes:p:prkaca|PRKACA]]|0.41|
|[[:human genes:r:rhoh|RHOH]]|0.407|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 2/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|2/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 17723
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.09 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='MIDN Expression in NALM6 Cells: 6.09'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>