MIDN

Gene Information

Official Symbol: MIDN
Official Name: midnolin
Aliases and Previous Symbols: N/A
Entrez ID: 90007
UniProt: Q504T8
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: Facilitates ubiquitin-independent proteasomal degradation of polycomb protein CBX4. Plays a role in inhibiting the activity of glucokinase GCK and both glucose-induced and basal insulin secretion. {ECO:0000250|UniProtKB:D4AE48, ECO:0000250|UniProtKB:Q3TPJ7}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
TRAIL 50ng/ml R00 exp36	-3.03
Vemurafenib 6.6μM R02 exp89	-2.52
TRAIL 5ng/ml R00 exp35	-2.33
Q15 2.7μM R02 exp79	-2.27
FBS-Wisent 0.1 R07 exp426	-2.03
Vemurafenib 6.6μM R08 exp434	-1.98
ABT-702 5μM plus CoCl2 18μM R07 exp320	-1.85
ABT-702 5μM plus Deferoxamine 11μM R07 exp321	-1.83
AICAR 240μM R05 exp211	1.71
Doxorubicin 0.02μM R08 exp478	1.71
Rotenone 0.07μM R08 exp431	1.71
Latrunculin-B 10μM R07 exp374	1.72
Cannabidiol 20μM R08 exp466	1.73
MS023 2μM R03 exp134	1.79
Benzoate 20000μM R08 exp456	1.85
GSK591 2.6μM R03 exp128	1.87
Sulforaphane 9μM R08 exp525	1.99
ML-792 0.2μM R08 exp505	2.04
Milciclib 2μM R08 exp502	2.52
MLN-4924 0.2μM R00 exp21	2.55
LY2090314 0.003μM R08 exp500 no dilution day6	2.67
Citral 75μM R06 exp275	2.85
LY2090314 0.003μM R08 exp499	2.86
THZ531 0.225μM R08 exp444	2.98
Vincristine 0.0005μM R04 exp190	2.99
Staurosporine 0.02μM R08 exp524	4.12

Global Fraction of Cell Lines Where Essential: 2/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	2/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 17723
Expression level (log2 read counts): 6.09

Expression Distribution

Gene	Correlation
METTL3	0.444
CD19	0.416
MAPKAP1	0.411
PRKACA	0.41
RHOH	0.407

negative regulation of glucokinase activity
negative regulation of hexokinase activity
regulation of glucokinase activity
regulation of hexokinase activity
negative regulation of insulin secretion
negative regulation of cellular carbohydrate metabolic process
negative regulation of peptide hormone secretion
negative regulation of carbohydrate metabolic process
negative regulation of hormone secretion
kinase binding
regulation of glucose metabolic process
negative regulation of protein secretion
negative regulation of peptide secretion
regulation of cellular carbohydrate metabolic process
regulation of insulin secretion
negative regulation of protein transport
negative regulation of establishment of protein localization
negative regulation of secretion by cell
regulation of carbohydrate metabolic process
regulation of peptide hormone secretion
negative regulation of secretion
negative regulation of kinase activity
regulation of hormone secretion
negative regulation of transferase activity
regulation of small molecule metabolic process
negative regulation of phosphorylation
regulation of protein secretion
negative regulation of transport
regulation of peptide secretion
regulation of hormone levels
negative regulation of phosphate metabolic process
negative regulation of phosphorus metabolic process
regulation of protein transport
regulation of peptide transport
regulation of establishment of protein localization
regulation of secretion by cell
molecular function
negative regulation of catalytic activity
regulation of secretion
nucleolus