MIEF2

Gene Information

Official Symbol: MIEF2
Official Name: mitochondrial elongation factor 2
Aliases and Previous Symbols: N/A
Entrez ID: 125170
UniProt: Q96C03
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: Mitochondrial outer membrane protein which regulates mitochondrial fission. Promotes the recruitment and association of the fission mediator dynamin-related protein 1 (DNM1L) to the mitochondrial surface independently of the mitochondrial fission FIS1 and MFF proteins. Regulates DNM1L GTPase activity. {ECO:0000269|PubMed:21508961, ECO:0000269|PubMed:23283981, ECO:0000269|PubMed:23530241, ECO:0000269|PubMed:23921378}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 1/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 6593
Expression level (log2 read counts): 3.34

Expression Distribution

positive regulation of protein homooligomerization
positive regulation of mitochondrial fission
mitochondrial fusion
regulation of protein homooligomerization
regulation of mitochondrial fission
positive regulation of protein oligomerization
positive regulation of protein targeting to membrane
regulation of protein targeting to membrane
regulation of protein oligomerization
regulation of protein targeting
organelle fusion
peroxisome
positive regulation of mitochondrion organization
positive regulation of protein localization to membrane
positive regulation of intracellular protein transport
mitochondrial outer membrane
regulation of mitochondrion organization
regulation of protein localization to membrane
positive regulation of intracellular transport
regulation of intracellular protein transport
positive regulation of protein complex assembly
positive regulation of cellular protein localization
regulation of intracellular transport
positive regulation of protein transport
mitochondrion organization
regulation of protein complex assembly
positive regulation of establishment of protein localization
positive regulation of cellular component biogenesis
regulation of cellular protein localization
positive regulation of organelle organization
regulation of protein transport
regulation of peptide transport
regulation of establishment of protein localization
regulation of cellular localization
regulation of cellular component biogenesis
positive regulation of transport
regulation of protein localization
regulation of anatomical structure morphogenesis
positive regulation of cellular component organization
mitochondrion