MISP

Entrez Summary: N/A
UniProt Summary: Plays a role in mitotic spindle orientation and mitotic progression. Regulates the distribution of dynactin at the cell cortex in a PLK1-dependent manner, thus stabilizing cortical and astral microtubule attachments required for proper mitotic spindle positioning. May link microtubules to the actin cytospkeleton and focal adhesions. May be required for directed cell migration and centrosome orientation. May also be necessary for proper stacking of the Golgi apparatus. {ECO:0000269|PubMed:23509069, ECO:0000269|PubMed:23574715}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

mitotic spindle astral microtubule end
regulation of protein localization to cell cortex
establishment of centrosome localization
spindle pole centrosome
establishment of mitotic spindle orientation
centrosome localization
microtubule organizing center localization
establishment of mitotic spindle localization
establishment of spindle orientation
mitotic spindle assembly
establishment of spindle localization
spindle localization
cortical actin cytoskeleton
adherens junction
mitotic spindle organization
actin filament
spindle assembly
microtubule cytoskeleton organization involved in mitosis
regulation of protein localization to cell periphery
establishment of cell polarity
mitotic nuclear division
spindle organization
establishment or maintenance of cell polarity
actin filament binding
nuclear division
organelle fission
establishment of organelle localization
focal adhesion
microtubule cytoskeleton organization
cell division
regulation of cellular protein localization
organelle localization
mitotic cell cycle process
microtubule-based process
mitotic cell cycle
intracellular membrane-bounded organelle
organelle assembly
regulation of cellular localization
cell migration
cell cycle process