MIXL1

Entrez Summary: N/A
UniProt Summary: Transcription factor that play a central role in proper axial mesendoderm morphogenesis and endoderm formation. Required for efficient differentiation of cells from the primitive streak stage to blood, by acting early in the recruitment and/or expansion of mesodermal progenitors to the hemangioblastic and hematopoietic lineages. Also involved in the morphogenesis of the heart and the gut during embryogenesis. Acts as a negative regulator of brachyury expression (By similarity). {ECO:0000250}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

positive regulation of mesoderm development
negative regulation of hematopoietic progenitor cell differentiation
cell migration involved in gastrulation
regulation of mesoderm development
proximal promoter sequence-specific DNA binding
RNA polymerase II repressing transcription factor binding
endodermal cell differentiation
endoderm formation
RNA polymerase II transcription factor binding
endoderm development
regulation of hematopoietic progenitor cell differentiation
hematopoietic progenitor cell differentiation
RNA polymerase II distal enhancer sequence-specific DNA binding
formation of primary germ layer
digestive tract development
negative regulation of hemopoiesis
digestive system development
gastrulation
ameboidal-type cell migration
nuclear chromatin
negative regulation of immune system process
DNA-binding transcription activator activity, RNA polymerase II-specific
regulation of hemopoiesis
RNA polymerase II proximal promoter sequence-specific DNA binding
heart development
hemopoiesis
embryonic morphogenesis
hematopoietic or lymphoid organ development
immune system development
negative regulation of cell differentiation
tube development
circulatory system development
protein homodimerization activity
anatomical structure formation involved in morphogenesis
negative regulation of developmental process
cell migration
embryo development
cell motility
localization of cell
negative regulation of multicellular organismal process