MLH3

Entrez Summary: This gene is a member of the MutL-homolog (MLH) family of DNA mismatch repair (MMR) genes. MLH genes are implicated in maintaining genomic integrity during DNA replication and after meiotic recombination. The protein encoded by this gene functions as a heterodimer with other family members. Somatic mutations in this gene frequently occur in tumors exhibiting microsatellite instability, and germline mutations have been linked to hereditary nonpolyposis colorectal cancer type 7 (HNPCC7). Several alternatively spliced transcript variants have been identified, but the full-length nature of only two transcript variants has been determined. [provided by RefSeq, Jul 2008].
UniProt Summary: Probably involved in the repair of mismatches in DNA.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

chiasma
satellite DNA binding
centromeric DNA binding
female meiosis I
MutLalpha complex
mismatched DNA binding
mismatch repair complex
male germ cell nucleus
synaptonemal complex assembly
synaptonemal complex organization
synaptonemal complex
female meiotic nuclear division
mismatch repair
synapsis
male meiotic nuclear division
reciprocal meiotic recombination
homologous recombination
homologous chromosome segregation
chromosome organization involved in meiotic cell cycle
meiotic chromosome segregation
meiosis I
meiosis I cell cycle process
female gamete generation
meiotic nuclear division
meiotic cell cycle process
nuclear chromosome segregation
DNA recombination
meiotic cell cycle
ATPase activity
chromosome segregation
nuclear division
organelle fission
cellular process involved in reproduction in multicellular organism
chromatin binding
DNA repair
male gamete generation
gamete generation
DNA metabolic process
cellular response to DNA damage stimulus
multicellular organismal reproductive process