MLLT11

Entrez Summary: N/A
UniProt Summary: Cofactor for the transcription factor TCF7 (PubMed:26079538). Involved in regulation of lymphoid development by driving multipotent hematopoietic progenitor cells towards a T cell fate (PubMed:21715312). {ECO:0000269|PubMed:21715312, ECO:0000269|PubMed:26079538}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Screen	Score
Celastrol 0.12μM R05 exp225	-1.8
DABN 20μM R00 exp17	1.83

positive regulation of mitochondrial depolarization
positive regulation of membrane depolarization
regulation of mitochondrial depolarization
positive regulation of release of cytochrome c from mitochondria
regulation of membrane depolarization
regulation of release of cytochrome c from mitochondria
regulation of mitochondrial membrane potential
extrinsic apoptotic signaling pathway
positive regulation of mitochondrion organization
intrinsic apoptotic signaling pathway
microtubule organizing center
positive regulation of apoptotic signaling pathway
regulation of mitochondrion organization
apoptotic signaling pathway
regulation of apoptotic signaling pathway
regulation of membrane potential
positive regulation of organelle organization
positive regulation of apoptotic process
positive regulation of programmed cell death
positive regulation of cell death
molecular function
ion homeostasis
apoptotic process
programmed cell death
cell death
chemical homeostasis
positive regulation of cellular component organization
regulation of organelle organization
positive regulation of transcription, DNA-templated
regulation of apoptotic process
regulation of programmed cell death
positive regulation of nucleic acid-templated transcription
positive regulation of RNA biosynthetic process
homeostatic process
positive regulation of signal transduction
regulation of cell death
intracellular signal transduction
positive regulation of RNA metabolic process
positive regulation of cell communication
positive regulation of signaling