MMAB

Entrez Summary: This gene encodes a protein that catalyzes the final step in the conversion of vitamin B(12) into adenosylcobalamin (AdoCbl), a vitamin B12-containing coenzyme for methylmalonyl-CoA mutase. Mutations in the gene are the cause of vitamin B12-dependent methylmalonic aciduria linked to the cblB complementation group. Alternatively spliced transcript variants have been found. [provided by RefSeq, Apr 2011].
UniProt Summary: Adenosyltransferase involved in intracellular vitamin B12 metabolism. Generates adenosylcobalamin (AdoCbl) and directly delivers the cofactor to MUT in a transfer taht is stimulated by ATP-binding to MMAB and gated by MMAA. {ECO:0000305|PubMed:28497574}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Screen	Score
Tanespimycin 14μM R08 exp527	-1.93
RO-3307 4.7μM R02 exp80	1.96

cob(I)yrinic acid a,c-diamide adenosyltransferase activity
cobalamin biosynthetic process
water-soluble vitamin biosynthetic process
cobalamin binding
vitamin biosynthetic process
cobalamin metabolic process
tetrapyrrole biosynthetic process
tetrapyrrole metabolic process
water-soluble vitamin metabolic process
vitamin metabolic process
cofactor biosynthetic process
mitochondrial matrix
cofactor metabolic process
drug metabolic process
small molecule biosynthetic process
heterocycle biosynthetic process
aromatic compound biosynthetic process
organic cyclic compound biosynthetic process
organonitrogen compound biosynthetic process
ATP binding
cellular nitrogen compound biosynthetic process
small molecule metabolic process