MMGT1 [The Human Chemical-Genetic Interaction Map Project]

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======= MMGT1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: MMGT1
  * **<color #00a2e8>Official Name</color>**: membrane magnesium transporter 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=93380|93380]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q8N4V1|Q8N4V1]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=MMGT1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20MMGT1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/301098|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Mediates Mg(2+) transport. {ECO:0000250|UniProtKB:Q8K273}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|MMgT|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|inorganic cation transmembrane transporter activity|
|ER membrane protein complex|
|magnesium ion transmembrane transport|
|magnesium ion transmembrane transporter activity|
|magnesium ion transport|
|early endosome membrane|
|early endosome|
|divalent metal ion transport|
|divalent inorganic cation transport|
|inorganic cation transmembrane transport|
|cation transmembrane transport|
|Golgi membrane|
|metal ion transport|
|inorganic ion transmembrane transport|
|cation transport|
|ion transmembrane transport|
|Golgi apparatus|
|transmembrane transport|
|ion transport|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp466|Cannabidiol 20μM R08 exp466]]|-3.22|
|[[:results:exp444|THZ531 0.225μM R08 exp444]]|-2.65|
|[[:results:exp454|Bafilomycin-A1 0.009μM R08 exp454]]|-2.39|
|[[:results:exp89|Vemurafenib 6.6μM R02 exp89]]|-2.09|
|[[:results:exp73|LJH685 5μM R02 exp73]]|-2.07|
|[[:results:exp412|THZ531 0.11 to 0.125 to 0.35μM on day4 then day6 R07 exp412]]|-2.05|
|[[:results:exp164|Q15 1 to 2μM on day4 R04 exp164]]|-1.97|
|[[:results:exp409|THZ531 0.11μM R07 exp409]]|-1.92|
|[[:results:exp507|Monensin 0.3μM R08 exp507]]|-1.85|
|[[:results:exp160|Ribavirin 10 to 15μM on day4 R04 exp160]]|-1.83|
|[[:results:exp287|HMS-I2 5μM R06 exp287]]|-1.82|
|[[:results:exp301|VER-155008 3.9μM R06 exp301]]|-1.78|
|[[:results:exp147|Resveratrol 16μM R03 exp147]]|-1.77|
|[[:results:exp374|Latrunculin-B 10μM R07 exp374]]|1.7|
|[[:results:exp82|Torin1 0.08μM R02 exp82]]|1.73|
|[[:results:exp400|Senexin-A 25μM R07 exp400]]|1.79|
|[[:results:exp307|Rapamycin 2μM plus Cyclosporin-A 3μM R07 exp307]]|1.85|
|[[:results:exp30|Rapamycin 10μM R00 exp30]]|1.86|
|[[:results:exp488|Hippuristanol 0.12μM R08 exp488]]|1.87|
|[[:results:exp212|Phenformin 20μM R05 exp212]]|1.96|
|[[:results:exp447|Amiloride 100μM R08 exp447]]|2.01|
|[[:results:exp246|UM0011500 10μM R05 exp246]]|2.73|
|[[:results:exp306|Rapamycin 2μM R07 exp306]]|2.81|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:e:emc2|EMC2]]|0.661|
|[[:human genes:e:emc6|EMC6]]|0.603|
|[[:human genes:e:emc1|EMC1]]|0.575|
|[[:human genes:e:emc4|EMC4]]|0.468|
|[[:human genes:e:emc3|EMC3]]|0.464|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 65/694
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|2/28|
|blood|9/26|
|bone|4/26|
|breast|1/30|
|central nervous system|2/49|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/11|
|fibroblast|1/1|
|gastric|1/14|
|kidney|3/18|
|liver|2/19|
|lung|4/72|
|lymphocyte|3/16|
|ovary|3/25|
|pancreas|1/22|
|peripheral nervous system|0/15|
|plasma cell|1/12|
|prostate|0/1|
|skin|1/20|
|soft tissue|1/9|
|thyroid|0/2|
|upper aerodigestive|3/22|
|urinary tract|1/28|
|uterus|2/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 1087
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.09 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='MMGT1 Expression in NALM6 Cells: 5.09'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>