MMGT1

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Cannabidiol 20μM R08 exp466	-3.22
THZ531 0.225μM R08 exp444	-2.65
Bafilomycin-A1 0.009μM R08 exp454	-2.39
Vemurafenib 6.6μM R02 exp89	-2.09
LJH685 5μM R02 exp73	-2.07
THZ531 0.11 to 0.125 to 0.35μM on day4 then day6 R07 exp412	-2.05
Q15 1 to 2μM on day4 R04 exp164	-1.97
THZ531 0.11μM R07 exp409	-1.92
Monensin 0.3μM R08 exp507	-1.85
Ribavirin 10 to 15μM on day4 R04 exp160	-1.83
HMS-I2 5μM R06 exp287	-1.82
VER-155008 3.9μM R06 exp301	-1.78
Resveratrol 16μM R03 exp147	-1.77
Latrunculin-B 10μM R07 exp374	1.7
Torin1 0.08μM R02 exp82	1.73
Senexin-A 25μM R07 exp400	1.79
Rapamycin 2μM plus Cyclosporin-A 3μM R07 exp307	1.85
Rapamycin 10μM R00 exp30	1.86
Hippuristanol 0.12μM R08 exp488	1.87
Phenformin 20μM R05 exp212	1.96
Amiloride 100μM R08 exp447	2.01
UM0011500 10μM R05 exp246	2.73
Rapamycin 2μM R07 exp306	2.81

Global Fraction of Cell Lines Where Essential: 65/694

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	2/28
blood	9/26
bone	4/26
breast	1/30
central nervous system	2/49
cervix	0/4
colorectal	0/17
esophagus	0/11
fibroblast	1/1
gastric	1/14
kidney	3/18
liver	2/19
lung	4/72
lymphocyte	3/16
ovary	3/25
pancreas	1/22
peripheral nervous system	0/15
plasma cell	1/12
prostate	0/1
skin	1/20
soft tissue	1/9
thyroid	0/2
upper aerodigestive	3/22
urinary tract	1/28
uterus	2/5

Expression Distribution

inorganic cation transmembrane transporter activity
ER membrane protein complex
magnesium ion transmembrane transport
magnesium ion transmembrane transporter activity
magnesium ion transport
early endosome membrane
early endosome
divalent metal ion transport
divalent inorganic cation transport
inorganic cation transmembrane transport
cation transmembrane transport
Golgi membrane
metal ion transport
inorganic ion transmembrane transport
cation transport
ion transmembrane transport
Golgi apparatus
transmembrane transport
ion transport
membrane