MMP14 [The Human Chemical-Genetic Interaction Map Project]

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======= MMP14 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: MMP14
  * **<color #00a2e8>Official Name</color>**: matrix metallopeptidase 14
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=4323|4323]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P50281|P50281]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=MMP14&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20MMP14|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/600754|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. However, the protein encoded by this gene is a member of the membrane-type MMP (MT-MMP) subfamily; each member of this subfamily contains a potential transmembrane domain suggesting that these proteins are expressed at the cell surface rather than secreted. This protein activates MMP2 protein, and this activity may be involved in tumor invasion. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Endopeptidase that degrades various components of the extracellular matrix such as collagen. Activates progelatinase A. Essential for pericellular collagenolysis and modeling of skeletal and extraskeletal connective tissues during development (By similarity). May be involved in actin cytoskeleton reorganization by cleaving PTK7 (PubMed:20837484). Acts as a positive regulator of cell growth and migration via activation of MMP15. Involved in the formation of the fibrovascular tissues in association with pro-MMP2 (PubMed:12714657). Cleaves ADGRB1 to release vasculostatin-40 which inhibits angiogenesis (PubMed:22330140). {ECO:0000250|UniProtKB:P53690, ECO:0000269|PubMed:12714657, ECO:0000269|PubMed:20837484, ECO:0000269|PubMed:22065321, ECO:0000269|PubMed:22330140}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Peptidase M10|
|DUF3377|
|PG binding 1|
|Hemopexin|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|response to odorant|
|astrocyte cell migration|
|macropinosome|
|chondrocyte proliferation|
|positive regulation of B cell differentiation|
|craniofacial suture morphogenesis|
|negative regulation of focal adhesion assembly|
|positive regulation of macrophage migration|
|negative regulation of adherens junction organization|
|endothelial cell proliferation|
|negative regulation of cell junction assembly|
|positive regulation of protein processing|
|metalloaminopeptidase activity|
|positive regulation of protein maturation|
|regulation of B cell differentiation|
|replacement ossification|
|endochondral ossification|
|positive regulation of myotube differentiation|
|glial cell migration|
|regulation of macrophage migration|
|negative regulation of cell-matrix adhesion|
|zymogen activation|
|endodermal cell differentiation|
|negative regulation of Notch signaling pathway|
|collagen catabolic process|
|embryonic cranial skeleton morphogenesis|
|intermediate filament cytoskeleton|
|endoderm formation|
|ovarian follicle development|
|regulation of myotube differentiation|
|positive regulation of striated muscle cell differentiation|
|regulation of focal adhesion assembly|
|regulation of cell-substrate junction assembly|
|negative regulation of cell-substrate adhesion|
|extracellular matrix disassembly|
|collagen metabolic process|
|cranial skeletal system development|
|regulation of protein processing|
|regulation of adherens junction organization|
|regulation of protein maturation|
|endochondral bone morphogenesis|
|endoderm development|
|response to estrogen|
|endopeptidase activity|
|epithelial cell proliferation|
|positive regulation of muscle cell differentiation|
|female gonad development|
|regulation of cell junction assembly|
|development of primary female sexual characteristics|
|embryonic skeletal system morphogenesis|
|positive regulation of lymphocyte differentiation|
|regulation of protein localization to plasma membrane|
|Golgi lumen|
|tissue remodeling|
|melanosome|
|regulation of striated muscle cell differentiation|
|regulation of Notch signaling pathway|
|metalloendopeptidase activity|
|female sex differentiation|
|formation of primary germ layer|
|bone morphogenesis|
|regulation of protein localization to cell periphery|
|regulation of cell-matrix adhesion|
|embryonic skeletal system development|
|positive regulation of leukocyte migration|
|integrin binding|
|branching morphogenesis of an epithelial tube|
|male gonad development|
|development of primary male sexual characteristics|
|positive regulation of leukocyte differentiation|
|regulation of muscle cell differentiation|
|male sex differentiation|
|protein processing|
|morphogenesis of a branching epithelium|
|gastrulation|
|positive regulation of cell growth|
|positive regulation of B cell activation|
|morphogenesis of a branching structure|
|regulation of lymphocyte differentiation|
|lung development|
|respiratory tube development|
|positive regulation of hemopoiesis|
|regulation of protein localization to membrane|
|respiratory system development|
|regulation of leukocyte migration|
|bone development|
|regulation of B cell activation|
|gonad development|
|regulation of cell-substrate adhesion|
|response to mechanical stimulus|
|gliogenesis|
|development of primary sexual characteristics|
|protein maturation|
|extracellular matrix|
|skeletal system morphogenesis|
|cytoplasmic vesicle|
|positive regulation of growth|
|ossification|
|sex differentiation|
|negative regulation of cell adhesion|
|regulation of leukocyte differentiation|
|embryonic organ morphogenesis|
|epithelial tube morphogenesis|
|angiogenesis|
|extracellular matrix organization|
|response to hypoxia|
|response to decreased oxygen levels|
|positive regulation of proteolysis|
|positive regulation of lymphocyte activation|
|response to oxygen levels|
|response to oxidative stress|
|extracellular structure organization|
|cellular component disassembly|
|positive regulation of leukocyte activation|
|blood vessel morphogenesis|
|focal adhesion|
|positive regulation of cell activation|
|regulation of cell growth|
|reproductive structure development|
|reproductive system development|
|morphogenesis of an epithelium|
|embryonic organ development|
|regulation of hemopoiesis|
|blood vessel development|
|skeletal system development|
|positive regulation of cell migration|
|vasculature development|
|regulation of lymphocyte activation|
|cardiovascular system development|
|positive regulation of cell motility|
|positive regulation of cellular component movement|
|regulation of cellular protein localization|
|positive regulation of locomotion|
|cell population proliferation|
|tissue morphogenesis|
|embryonic morphogenesis|
|regulation of leukocyte activation|
|chordate embryonic development|
|regulation of cell activation|
|embryo development ending in birth or egg hatching|
|tube morphogenesis|
|developmental process involved in reproduction|
|regulation of growth|
|regulation of cell adhesion|
|negative regulation of cellular component organization|
|regulation of proteolysis|
|head development|
|zinc ion binding|
|tube development|
|regulation of cell migration|
|circulatory system development|
|anatomical structure formation involved in morphogenesis|
|response to hormone|
|regulation of cell motility|
|regulation of cellular localization|
|response to organic cyclic compound|
|animal organ morphogenesis|
|regulation of cellular component biogenesis|
|cell migration|
|positive regulation of cell differentiation|
|embryo development|
|regulation of locomotion|
|regulation of cellular component movement|
|regulation of protein localization|
|cell motility|
|localization of cell|
|epithelium development|
|positive regulation of immune system process|
|response to abiotic stimulus|
|negative regulation of signal transduction|
|proteolysis|
|locomotion|
|negative regulation of cell communication|
|negative regulation of signaling|
|positive regulation of developmental process|
|integral component of plasma membrane|
|reproductive process|
|reproduction|
|response to endogenous stimulus|
|movement of cell or subcellular component|
|extracellular space|
|positive regulation of cellular protein metabolic process|
|negative regulation of response to stimulus|
|neurogenesis|
|regulation of immune system process|
|positive regulation of protein metabolic process|
|positive regulation of multicellular organismal process|
|tissue development|
|regulation of cell differentiation|
|positive regulation of gene expression|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 7317
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 2.39 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='MMP14 Expression in NALM6 Cells: 2.39'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>