MMP14

Gene Information

Official Symbol: MMP14
Official Name: matrix metallopeptidase 14
Aliases and Previous Symbols: N/A
Entrez ID: 4323
UniProt: P50281
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. However, the protein encoded by this gene is a member of the membrane-type MMP (MT-MMP) subfamily; each member of this subfamily contains a potential transmembrane domain suggesting that these proteins are expressed at the cell surface rather than secreted. This protein activates MMP2 protein, and this activity may be involved in tumor invasion. [provided by RefSeq, Jul 2008].
UniProt Summary: Endopeptidase that degrades various components of the extracellular matrix such as collagen. Activates progelatinase A. Essential for pericellular collagenolysis and modeling of skeletal and extraskeletal connective tissues during development (By similarity). May be involved in actin cytoskeleton reorganization by cleaving PTK7 (PubMed:20837484). Acts as a positive regulator of cell growth and migration via activation of MMP15. Involved in the formation of the fibrovascular tissues in association with pro-MMP2 (PubMed:12714657). Cleaves ADGRB1 to release vasculostatin-40 which inhibits angiogenesis (PubMed:22330140). {ECO:0000250|UniProtKB:P53690, ECO:0000269|PubMed:12714657, ECO:0000269|PubMed:20837484, ECO:0000269|PubMed:22065321, ECO:0000269|PubMed:22330140}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 7317
Expression level (log2 read counts): 2.39

Expression Distribution

Peptidase M10
DUF3377
PG binding 1
Hemopexin

response to odorant
astrocyte cell migration
macropinosome
chondrocyte proliferation
positive regulation of B cell differentiation
craniofacial suture morphogenesis
negative regulation of focal adhesion assembly
positive regulation of macrophage migration
negative regulation of adherens junction organization
endothelial cell proliferation
negative regulation of cell junction assembly
positive regulation of protein processing
metalloaminopeptidase activity
positive regulation of protein maturation
regulation of B cell differentiation
replacement ossification
endochondral ossification
positive regulation of myotube differentiation
glial cell migration
regulation of macrophage migration
negative regulation of cell-matrix adhesion
zymogen activation
endodermal cell differentiation
negative regulation of Notch signaling pathway
collagen catabolic process
embryonic cranial skeleton morphogenesis
intermediate filament cytoskeleton
endoderm formation
ovarian follicle development
regulation of myotube differentiation
positive regulation of striated muscle cell differentiation
regulation of focal adhesion assembly
regulation of cell-substrate junction assembly
negative regulation of cell-substrate adhesion
extracellular matrix disassembly
collagen metabolic process
cranial skeletal system development
regulation of protein processing
regulation of adherens junction organization
regulation of protein maturation