MMRN2 [The Human Chemical-Genetic Interaction Map Project]

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======= MMRN2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: MMRN2
  * **<color #00a2e8>Official Name</color>**: multimerin 2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=79812|79812]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9H8L6|Q9H8L6]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=MMRN2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20MMRN2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/608925|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a protein belonging to the member of elastin microfibril interface-located (EMILIN) protein family. This family member is an extracellular matrix glycoprotein that can interfere with tumor angiogenesis and growth. It serves as a transforming growth factor beta antagonist and can interfere with the VEGF-A/VEGFR2 pathway. A related pseudogene has been identified on chromosome 6. [provided by RefSeq, Aug 2012]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Inhibits endothelial cells motility and acts as a negative regulator of angiogenesis; it downregulates KDR activation by binding VEGFA. {ECO:0000269|PubMed:22020326}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|C1q|
|EMI|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|negative regulation of vascular endothelial growth factor receptor signaling pathway|
|negative regulation of cell migration involved in sprouting angiogenesis|
|cell migration involved in sprouting angiogenesis|
|negative regulation of sprouting angiogenesis|
|blood vessel endothelial cell migration|
|negative regulation of blood vessel endothelial cell migration|
|regulation of vascular endothelial growth factor receptor signaling pathway|
|regulation of cell migration involved in sprouting angiogenesis|
|negative regulation of endothelial cell migration|
|sprouting angiogenesis|
|endothelial cell migration|
|negative regulation of epithelial cell migration|
|regulation of sprouting angiogenesis|
|epithelial cell migration|
|epithelium migration|
|basement membrane|
|regulation of blood vessel endothelial cell migration|
|tissue migration|
|negative regulation of angiogenesis|
|negative regulation of blood vessel morphogenesis|
|negative regulation of vasculature development|
|positive regulation of cell-substrate adhesion|
|extracellular matrix structural constituent|
|negative regulation of cellular response to growth factor stimulus|
|regulation of endothelial cell migration|
|ameboidal-type cell migration|
|regulation of cell-substrate adhesion|
|regulation of epithelial cell migration|
|extracellular matrix|
|negative regulation of cell migration|
|regulation of cellular response to growth factor stimulus|
|negative regulation of cell motility|
|regulation of angiogenesis|
|negative regulation of cellular component movement|
|angiogenesis|
|regulation of vasculature development|
|negative regulation of locomotion|
|collagen-containing extracellular matrix|
|positive regulation of cell adhesion|
|blood vessel morphogenesis|
|blood vessel development|
|vasculature development|
|cardiovascular system development|
|tube morphogenesis|
|regulation of cell adhesion|
|tube development|
|regulation of cell migration|
|circulatory system development|
|anatomical structure formation involved in morphogenesis|
|regulation of cell motility|
|negative regulation of developmental process|
|cell migration|
|regulation of locomotion|
|regulation of cellular component movement|
|regulation of anatomical structure morphogenesis|
|localization of cell|
|cell motility|
|negative regulation of multicellular organismal process|
|negative regulation of signal transduction|
|locomotion|
|negative regulation of cell communication|
|negative regulation of signaling|
|movement of cell or subcellular component|
|extracellular space|
|negative regulation of response to stimulus|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 3078
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 0.61 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='MMRN2 Expression in NALM6 Cells: 0.61'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>