MMRN2

Gene Information

Official Symbol: MMRN2
Official Name: multimerin 2
Aliases and Previous Symbols: N/A
Entrez ID: 79812
UniProt: Q9H8L6
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: This gene encodes a protein belonging to the member of elastin microfibril interface-located (EMILIN) protein family. This family member is an extracellular matrix glycoprotein that can interfere with tumor angiogenesis and growth. It serves as a transforming growth factor beta antagonist and can interfere with the VEGF-A/VEGFR2 pathway. A related pseudogene has been identified on chromosome 6. [provided by RefSeq, Aug 2012].
UniProt Summary: Inhibits endothelial cells motility and acts as a negative regulator of angiogenesis; it downregulates KDR activation by binding VEGFA. {ECO:0000269|PubMed:22020326}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 3078
Expression level (log2 read counts): 0.61

Expression Distribution

C1q
EMI

negative regulation of vascular endothelial growth factor receptor signaling pathway
negative regulation of cell migration involved in sprouting angiogenesis
cell migration involved in sprouting angiogenesis
negative regulation of sprouting angiogenesis
blood vessel endothelial cell migration
negative regulation of blood vessel endothelial cell migration
regulation of vascular endothelial growth factor receptor signaling pathway
regulation of cell migration involved in sprouting angiogenesis
negative regulation of endothelial cell migration
sprouting angiogenesis
endothelial cell migration
negative regulation of epithelial cell migration
regulation of sprouting angiogenesis
epithelial cell migration
epithelium migration
basement membrane
regulation of blood vessel endothelial cell migration
tissue migration
negative regulation of angiogenesis
negative regulation of blood vessel morphogenesis
negative regulation of vasculature development
positive regulation of cell-substrate adhesion
extracellular matrix structural constituent
negative regulation of cellular response to growth factor stimulus
regulation of endothelial cell migration
ameboidal-type cell migration
regulation of cell-substrate adhesion
regulation of epithelial cell migration
extracellular matrix
negative regulation of cell migration
regulation of cellular response to growth factor stimulus
negative regulation of cell motility
regulation of angiogenesis
negative regulation of cellular component movement
angiogenesis
regulation of vasculature development
negative regulation of locomotion
collagen-containing extracellular matrix
positive regulation of cell adhesion
blood vessel morphogenesis