MMS19 [The Human Chemical-Genetic Interaction Map Project]

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======= MMS19 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: MMS19
  * **<color #00a2e8>Official Name</color>**: MMS19 homolog, cytosolic iron-sulfur assembly component
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=64210|64210]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q96T76|Q96T76]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=MMS19&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20MMS19|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/614777|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|MMS19 N|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|phosphorelay signal transduction system|
|MMXD complex|
|CIA complex|
|positive regulation of double-strand break repair via homologous recombination|
|transcription factor TFIIH holo complex|
|protein maturation by iron-sulfur cluster transfer|
|metallo-sulfur cluster assembly|
|iron-sulfur cluster assembly|
|receptor signaling complex adaptor activity|
|positive regulation of double-strand break repair|
|positive regulation of DNA recombination|
|estrogen receptor binding|
|regulation of double-strand break repair via homologous recombination|
|positive regulation of DNA repair|
|regulation of double-strand break repair|
|protein binding, bridging|
|positive regulation of response to DNA damage stimulus|
|regulation of DNA recombination|
|nucleotide-excision repair|
|spindle|
|regulation of DNA repair|
|positive regulation of DNA metabolic process|
|cofactor biosynthetic process|
|regulation of response to DNA damage stimulus|
|protein maturation|
|chromosome segregation|
|transcription coactivator activity|
|enzyme binding|
|regulation of DNA metabolic process|
|sulfur compound metabolic process|
|cofactor metabolic process|
|DNA repair|
|transcription, DNA-templated|
|nucleic acid-templated transcription|
|RNA biosynthetic process|
|regulation of cellular response to stress|
|DNA metabolic process|
|cellular response to DNA damage stimulus|
|response to hormone|
|nucleobase-containing compound biosynthetic process|
|heterocycle biosynthetic process|
|aromatic compound biosynthetic process|
|organic cyclic compound biosynthetic process|
|response to endogenous stimulus|
|regulation of response to stress|
|positive regulation of transcription, DNA-templated|
|cellular nitrogen compound biosynthetic process|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|positive regulation of signal transduction|
|RNA metabolic process|
|intracellular signal transduction|
|cellular response to stress|
|cellular macromolecule biosynthetic process|
|positive regulation of RNA metabolic process|
|macromolecule biosynthetic process|
|positive regulation of cell communication|
|positive regulation of signaling|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|membrane|
|gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp320|ABT-702 5μM plus CoCl2 18μM R07 exp320]]|-1.98|
|[[:results:exp452|Azithromycin 100μM R08 exp452]]|-1.91|
|[[:results:exp330|5-Azacytidine 2μM R07 exp330]]|1.71|
|[[:results:exp352|Dexamethasone 0.006 to 0.015μM on day4 R07 exp352]]|1.81|
|[[:results:exp382|Palbociclib 1μM R07 exp382]]|1.88|
|[[:results:exp418|Tunicamycin 0.04μM R07 exp418]]|1.96|
|[[:results:exp191|Hypoxia 5%O2 R04 exp191]]|1.97|
|[[:results:exp379|MSC2530818 10μM R07 exp379]]|2.09|
|[[:results:exp420|Tunicamycin 0.04 to 0.125μM  on day4 R07 exp420]]|2.34|
|[[:results:exp326|CCT251545 20μM R07 exp326]]|2.44|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:f:fam96b|FAM96B]]|0.434|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 491/726
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|1/1|
|bile duct|17/28|
|blood|8/28|
|bone|22/25|
|breast|22/33|
|central nervous system|48/56|
|cervix|2/4|
|colorectal|8/17|
|esophagus|11/13|
|fibroblast|1/1|
|gastric|8/15|
|kidney|20/21|
|liver|13/20|
|lung|55/75|
|lymphocyte|7/14|
|ovary|20/26|
|pancreas|17/24|
|peripheral nervous system|9/16|
|plasma cell|4/15|
|prostate|0/1|
|skin|18/24|
|soft tissue|6/7|
|thyroid|2/2|
|upper aerodigestive|16/22|
|urinary tract|23/29|
|uterus|2/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 798
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 7.04 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='MMS19 Expression in NALM6 Cells: 7.04'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>