MMS19
Gene Information
- Official Symbol: MMS19
- Official Name: MMS19 homolog, cytosolic iron-sulfur assembly component
- Aliases and Previous Symbols: N/A
- Entrez ID: 64210
- UniProt: Q96T76
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: N/A
Pfam Domains GO Terms
Pfam Domains
| MMS19 N |
GO Terms
| phosphorelay signal transduction system |
| MMXD complex |
| CIA complex |
| positive regulation of double-strand break repair via homologous recombination |
| transcription factor TFIIH holo complex |
| protein maturation by iron-sulfur cluster transfer |
| metallo-sulfur cluster assembly |
| iron-sulfur cluster assembly |
| receptor signaling complex adaptor activity |
| positive regulation of double-strand break repair |
| positive regulation of DNA recombination |
| estrogen receptor binding |
| regulation of double-strand break repair via homologous recombination |
| positive regulation of DNA repair |
| regulation of double-strand break repair |
| protein binding, bridging |
| positive regulation of response to DNA damage stimulus |
| regulation of DNA recombination |
| nucleotide-excision repair |
| spindle |
| regulation of DNA repair |
| positive regulation of DNA metabolic process |
| cofactor biosynthetic process |
| regulation of response to DNA damage stimulus |
| protein maturation |
| chromosome segregation |
| transcription coactivator activity |
| enzyme binding |
| regulation of DNA metabolic process |
| sulfur compound metabolic process |
| cofactor metabolic process |
| DNA repair |
| transcription, DNA-templated |
| nucleic acid-templated transcription |
| RNA biosynthetic process |
| regulation of cellular response to stress |
| DNA metabolic process |
| cellular response to DNA damage stimulus |
| response to hormone |
| nucleobase-containing compound biosynthetic process |
| heterocycle biosynthetic process |
| aromatic compound biosynthetic process |
| organic cyclic compound biosynthetic process |
| response to endogenous stimulus |
| regulation of response to stress |
| positive regulation of transcription, DNA-templated |
| cellular nitrogen compound biosynthetic process |
| positive regulation of nucleic acid-templated transcription |
| positive regulation of RNA biosynthetic process |
| positive regulation of signal transduction |
| RNA metabolic process |
| intracellular signal transduction |
| cellular response to stress |
| cellular macromolecule biosynthetic process |
| positive regulation of RNA metabolic process |
| macromolecule biosynthetic process |
| positive regulation of cell communication |
| positive regulation of signaling |
| positive regulation of nucleobase-containing compound metabolic process |
| positive regulation of macromolecule biosynthetic process |
| positive regulation of cellular biosynthetic process |
| positive regulation of gene expression |
| membrane |
| gene expression |
| positive regulation of biosynthetic process |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
Most Correlated Genes in Chemogenomics
| Gene | Correlation |
|---|---|
| FAM96B | 0.434 |
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 491/726
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 1/1 |
| bile duct | 17/28 |
| blood | 8/28 |
| bone | 22/25 |
| breast | 22/33 |
| central nervous system | 48/56 |
| cervix | 2/4 |
| colorectal | 8/17 |
| esophagus | 11/13 |
| fibroblast | 1/1 |
| gastric | 8/15 |
| kidney | 20/21 |
| liver | 13/20 |
| lung | 55/75 |
| lymphocyte | 7/14 |
| ovary | 20/26 |
| pancreas | 17/24 |
| peripheral nervous system | 9/16 |
| plasma cell | 4/15 |
| prostate | 0/1 |
| skin | 18/24 |
| soft tissue | 6/7 |
| thyroid | 2/2 |
| upper aerodigestive | 16/22 |
| urinary tract | 23/29 |
| uterus | 2/5 |
Essentiality in NALM6
- Essentiality Rank: 798
- Expression level (log2 read counts): 7.04
Expression Distribution
MMS19 Expression in NALM6 Cells: 7.04
