MN1
Gene Information
- Official Symbol: MN1
- Official Name: MN1 proto-oncogene, transcriptional regulator
- Aliases and Previous Symbols: N/A
- Entrez ID: 4330
- UniProt: Q10571
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: Meningioma 1 (MN1) contains two sets of CAG repeats. It is disrupted by a balanced translocation (4;22) in a meningioma, and its inactivation may contribute to meningioma 32 pathogenesis. [provided by RefSeq, Jul 2008].
- UniProt Summary: Transcriptional activator which specifically regulates expression of TBX22 in the posterior region of the developing palate. Required during later stages of palate development for growth and medial fusion of the palatal shelves. Promotes maturation and normal function of calvarial osteoblasts, including expression of the osteoclastogenic cytokine TNFSF11/RANKL. Necessary for normal development of the membranous bones of the skull (By similarity). May play a role in tumor suppression (Probable). {ECO:0000250|UniProtKB:D3YWE6, ECO:0000305|PubMed:7731706}.
CRISPR Data
Essentiality in NALM6
- Essentiality Rank: 6330
- Expression level (log2 read counts): -1.72
MN1 Expression in NALM6 Cells: -1.72
