MNDA [The Human Chemical-Genetic Interaction Map Project]

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======= MNDA =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: MNDA
  * **<color #00a2e8>Official Name</color>**: myeloid cell nuclear differentiation antigen
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=4332|4332]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P41218|P41218]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=MNDA&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20MNDA|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/159553|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  May act as a transcriptional activator/repressor in the myeloid lineage. Plays a role in the granulocyte/monocyte cell- specific response to interferon. Stimulates the DNA binding of the transcriptional repressor protein YY1.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|PAAD DAPIN|
|HIN|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|negative regulation of B cell proliferation|
|cellular response to interferon-beta|
|response to interferon-beta|
|negative regulation of B cell activation|
|positive regulation of interleukin-1 beta production|
|cellular defense response|
|positive regulation of interleukin-1 production|
|regulation of B cell proliferation|
|negative regulation of lymphocyte proliferation|
|negative regulation of mononuclear cell proliferation|
|negative regulation of leukocyte proliferation|
|regulation of interleukin-1 beta production|
|azurophil granule lumen|
|regulation of interleukin-1 production|
|double-stranded DNA binding|
|ficolin-1-rich granule lumen|
|B cell receptor signaling pathway|
|negative regulation of lymphocyte activation|
|negative regulation of leukocyte activation|
|negative regulation of cell activation|
|regulation of B cell activation|
|regulation of lymphocyte proliferation|
|regulation of mononuclear cell proliferation|
|regulation of leukocyte proliferation|
|activation of innate immune response|
|antigen receptor-mediated signaling pathway|
|positive regulation of innate immune response|
|positive regulation of response to biotic stimulus|
|negative regulation of immune system process|
|positive regulation of cytokine production|
|immune response-activating cell surface receptor signaling pathway|
|regulation of innate immune response|
|positive regulation of defense response|
|immune response-regulating cell surface receptor signaling pathway|
|neutrophil degranulation|
|neutrophil activation involved in immune response|
|neutrophil mediated immunity|
|neutrophil activation|
|granulocyte activation|
|positive regulation of multi-organism process|
|leukocyte degranulation|
|regulation of lymphocyte activation|
|myeloid leukocyte mediated immunity|
|regulation of response to biotic stimulus|
|myeloid cell activation involved in immune response|
|immune response-activating signal transduction|
|myeloid leukocyte activation|
|immune response-regulating signaling pathway|
|regulation of leukocyte activation|
|positive regulation of response to external stimulus|
|leukocyte activation involved in immune response|
|cell activation involved in immune response|
|activation of immune response|
|regulation of cell activation|
|positive regulation of apoptotic process|
|positive regulation of programmed cell death|
|negative regulation of cell population proliferation|
|regulation of cytokine production|
|positive regulation of cell death|
|regulated exocytosis|
|regulation of defense response|
|leukocyte mediated immunity|
|regulation of multi-organism process|
|cellular response to DNA damage stimulus|
|exocytosis|
|nucleolus|
|positive regulation of immune response|
|leukocyte activation|
|secretion by cell|
|cellular response to cytokine stimulus|
|export from cell|
|cell activation|
|immune effector process|
|regulation of response to external stimulus|
|response to cytokine|
|secretion|
|positive regulation of immune system process|
|regulation of immune response|
|defense response|
|regulation of response to stress|
|regulation of apoptotic process|
|regulation of programmed cell death|
|regulation of cell population proliferation|
|regulation of immune system process|
|regulation of cell death|
|cellular response to stress|
|positive regulation of multicellular organismal process|
|immune response|
|extracellular region|
|vesicle-mediated transport|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:h:hgc6.3|HGC6.3]]|0.474|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 14605
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -7.68 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='MNDA Expression in NALM6 Cells: -7.68'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>