MNDA

Gene Information

Official Symbol: MNDA
Official Name: myeloid cell nuclear differentiation antigen
Aliases and Previous Symbols: N/A
Entrez ID: 4332
UniProt: P41218
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: May act as a transcriptional activator/repressor in the myeloid lineage. Plays a role in the granulocyte/monocyte cell- specific response to interferon. Stimulates the DNA binding of the transcriptional repressor protein YY1.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 14605
Expression level (log2 read counts): -7.68

Expression Distribution

PAAD DAPIN
HIN

negative regulation of B cell proliferation
cellular response to interferon-beta
response to interferon-beta
negative regulation of B cell activation
positive regulation of interleukin-1 beta production
cellular defense response
positive regulation of interleukin-1 production
regulation of B cell proliferation
negative regulation of lymphocyte proliferation
negative regulation of mononuclear cell proliferation
negative regulation of leukocyte proliferation
regulation of interleukin-1 beta production
azurophil granule lumen
regulation of interleukin-1 production
double-stranded DNA binding
ficolin-1-rich granule lumen
B cell receptor signaling pathway
negative regulation of lymphocyte activation
negative regulation of leukocyte activation
negative regulation of cell activation
regulation of B cell activation
regulation of lymphocyte proliferation
regulation of mononuclear cell proliferation
regulation of leukocyte proliferation
activation of innate immune response
antigen receptor-mediated signaling pathway
positive regulation of innate immune response
positive regulation of response to biotic stimulus
negative regulation of immune system process
positive regulation of cytokine production
immune response-activating cell surface receptor signaling pathway
regulation of innate immune response
positive regulation of defense response
immune response-regulating cell surface receptor signaling pathway
neutrophil degranulation
neutrophil activation involved in immune response
neutrophil mediated immunity
neutrophil activation
granulocyte activation
positive regulation of multi-organism process