MOAP1 [The Human Chemical-Genetic Interaction Map Project]

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======= MOAP1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: MOAP1
  * **<color #00a2e8>Official Name</color>**: modulator of apoptosis 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=64112|64112]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q96BY2|Q96BY2]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=MOAP1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20MOAP1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/609485|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Required for death receptor-dependent apoptosis. When associated with RASSF1, promotes BAX conformational change and translocation to mitochondrial membranes in response to TNF and TNFSF10 stimulation. {ECO:0000269|PubMed:15949439}.

<button type='default' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
No Pfam Domain information is available for this gene.
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|protein insertion into mitochondrial membrane involved in apoptotic signaling pathway|
|mitochondrial outer membrane permeabilization|
|positive regulation of mitochondrial membrane permeability involved in apoptotic process|
|mitochondrial outer membrane permeabilization involved in programmed cell death|
|protein insertion into mitochondrial membrane|
|positive regulation of mitochondrial membrane permeability|
|positive regulation of membrane permeability|
|regulation of mitochondrial membrane permeability involved in apoptotic process|
|positive regulation of release of cytochrome c from mitochondria|
|extrinsic apoptotic signaling pathway in absence of ligand|
|signal transduction in absence of ligand|
|extrinsic apoptotic signaling pathway via death domain receptors|
|protein insertion into membrane|
|regulation of release of cytochrome c from mitochondria|
|apoptotic mitochondrial changes|
|establishment of protein localization to mitochondrion|
|intrinsic apoptotic signaling pathway in response to DNA damage|
|regulation of mitochondrial membrane permeability|
|protein localization to mitochondrion|
|regulation of membrane permeability|
|extrinsic apoptotic signaling pathway|
|positive regulation of mitochondrion organization|
|mitochondrial membrane organization|
|intrinsic apoptotic signaling pathway|
|mitochondrial outer membrane|
|positive regulation of apoptotic signaling pathway|
|regulation of mitochondrion organization|
|mitochondrial transport|
|establishment of protein localization to membrane|
|apoptotic signaling pathway|
|ubiquitin protein ligase binding|
|regulation of apoptotic signaling pathway|
|establishment of protein localization to organelle|
|mitochondrion organization|
|protein localization to membrane|
|positive regulation of organelle organization|
|positive regulation of apoptotic process|
|positive regulation of programmed cell death|
|positive regulation of cell death|
|protein localization to organelle|
|cellular response to DNA damage stimulus|
|membrane organization|
|apoptotic process|
|programmed cell death|
|cell death|
|positive regulation of cellular component organization|
|mitochondrion|
|regulation of organelle organization|
|regulation of apoptotic process|
|regulation of programmed cell death|
|cellular protein localization|
|cellular macromolecule localization|
|establishment of protein localization|
|positive regulation of signal transduction|
|regulation of cell death|
|intracellular signal transduction|
|cellular response to stress|
|positive regulation of cell communication|
|positive regulation of signaling|
|establishment of localization in cell|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp316|Geldanamycin 0.015 to 0.025μM on day4 R07 exp316]]|-1.79|
|[[:results:exp357|Dorsomorphin 5μM R07 exp357]]|-1.75|
|[[:results:exp241|QNZ 0.01μM R05 exp241]]|2.27|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 17126
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 4.23 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='MOAP1 Expression in NALM6 Cells: 4.23'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>