MOAP1

Gene Information

Official Symbol: MOAP1
Official Name: modulator of apoptosis 1
Aliases and Previous Symbols: N/A
Entrez ID: 64112
UniProt: Q96BY2
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: Required for death receptor-dependent apoptosis. When associated with RASSF1, promotes BAX conformational change and translocation to mitochondrial membranes in response to TNF and TNFSF10 stimulation. {ECO:0000269|PubMed:15949439}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 17126
Expression level (log2 read counts): 4.23

Expression Distribution

Screen	Score
Geldanamycin 0.015 to 0.025μM on day4 R07 exp316	-1.79
Dorsomorphin 5μM R07 exp357	-1.75
QNZ 0.01μM R05 exp241	2.27

protein insertion into mitochondrial membrane involved in apoptotic signaling pathway
mitochondrial outer membrane permeabilization
positive regulation of mitochondrial membrane permeability involved in apoptotic process
mitochondrial outer membrane permeabilization involved in programmed cell death
protein insertion into mitochondrial membrane
positive regulation of mitochondrial membrane permeability
positive regulation of membrane permeability
regulation of mitochondrial membrane permeability involved in apoptotic process
positive regulation of release of cytochrome c from mitochondria
extrinsic apoptotic signaling pathway in absence of ligand
signal transduction in absence of ligand
extrinsic apoptotic signaling pathway via death domain receptors
protein insertion into membrane
regulation of release of cytochrome c from mitochondria
apoptotic mitochondrial changes
establishment of protein localization to mitochondrion
intrinsic apoptotic signaling pathway in response to DNA damage
regulation of mitochondrial membrane permeability
protein localization to mitochondrion
regulation of membrane permeability
extrinsic apoptotic signaling pathway
positive regulation of mitochondrion organization
mitochondrial membrane organization
intrinsic apoptotic signaling pathway
mitochondrial outer membrane
positive regulation of apoptotic signaling pathway
regulation of mitochondrion organization
mitochondrial transport
establishment of protein localization to membrane
apoptotic signaling pathway
ubiquitin protein ligase binding
regulation of apoptotic signaling pathway
establishment of protein localization to organelle
mitochondrion organization
protein localization to membrane
positive regulation of organelle organization
positive regulation of apoptotic process
positive regulation of programmed cell death
positive regulation of cell death
protein localization to organelle