MOGAT3

Entrez Summary: N/A
UniProt Summary: Catalyzes the formation of diacylglycerol from 2- monoacylglycerol and fatty acyl-CoA. Also able to catalyze the terminal step in triacylglycerol synthesis by using diacylglycerol and fatty acyl-CoA as substrates. Has a preference toward palmitoyl-CoA and oleoyl-CoA. May be involved in absorption of dietary fat in the small intestine by catalyzing the resynthesis of triacylglycerol in enterocytes. {ECO:0000269|PubMed:12618427}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

perinuclear endoplasmic reticulum membrane
diacylglycerol O-acyltransferase activity
2-acylglycerol O-acyltransferase activity
triglyceride biosynthetic process
glycerol metabolic process
acylglycerol biosynthetic process
neutral lipid biosynthetic process
alditol metabolic process
triglyceride metabolic process
acylglycerol metabolic process
neutral lipid metabolic process
polyol metabolic process
cellular carbohydrate metabolic process
glycerolipid biosynthetic process
alcohol metabolic process
glycerolipid metabolic process
organic hydroxy compound metabolic process
carbohydrate metabolic process
lipid biosynthetic process
endoplasmic reticulum membrane
cellular lipid metabolic process
lipid metabolic process
small molecule metabolic process