MPHOSPH10 [The Human Chemical-Genetic Interaction Map Project]

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======= MPHOSPH10 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: MPHOSPH10
  * **<color #00a2e8>Official Name</color>**: M-phase phosphoprotein 10
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=10199|10199]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O00566|O00566]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=MPHOSPH10&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20MPHOSPH10|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/605503|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Component of the 60-80S U3 small nucleolar ribonucleoprotein (U3 snoRNP). Required for the early cleavages during pre-18S ribosomal RNA processing.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Mpp10|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|Mpp10 complex|
|small nucleolar ribonucleoprotein complex|
|small-subunit processome|
|negative regulation of phosphatase activity|
|negative regulation of dephosphorylation|
|chromosome|
|regulation of phosphatase activity|
|regulation of dephosphorylation|
|rRNA processing|
|rRNA metabolic process|
|ribosome biogenesis|
|RNA splicing, via transesterification reactions|
|ncRNA processing|
|RNA splicing|
|negative regulation of hydrolase activity|
|ribonucleoprotein complex biogenesis|
|ncRNA metabolic process|
|negative regulation of phosphate metabolic process|
|negative regulation of phosphorus metabolic process|
|negative regulation of catalytic activity|
|nucleolus|
|RNA processing|
|negative regulation of molecular function|
|regulation of hydrolase activity|
|RNA binding|
|RNA metabolic process|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp34|Rotenone 20μM R00 exp34]]|-3.07|
|[[:results:exp96|BI-2536 0.02μM R03 exp96]]|-2.7|
|[[:results:exp487|Hinokiflavone 12μM R08 exp487]]|-2.19|
|[[:results:exp93|DABN racemic mixture R03 exp93]]|-1.86|
|[[:results:exp142|OICR-9429 10μM R03 exp142]]|-1.86|
|[[:results:exp28|Pimelic-diphenylamide-106 5μM R00 exp28]]|-1.84|
|[[:results:exp435|JQ1 0.8μM R08 exp435]]|-1.83|
|[[:results:exp486|Heregulin-B 44ng/ml R08 exp486]]|1.74|
|[[:results:exp420|Tunicamycin 0.04 to 0.125μM  on day4 R07 exp420]]|1.74|
|[[:results:exp23|Nocodazole 0.02μM R00 exp23]]|1.75|
|[[:results:exp159|Docetaxel 0.001 to 0.002μM on day4 R04 exp159]]|1.79|
|[[:results:exp300|VE-822 0.04μM R06 exp300]]|1.8|
|[[:results:exp495|IWR1 50μM R08 exp495]]|1.83|
|[[:results:exp514|Phorbol-12-myristate-13-acetate 0.57μM R08 exp514]]|1.86|
|[[:results:exp225|Celastrol 0.12μM R05 exp225]]|1.89|
|[[:results:exp54|Taxol 0.002μM R01 exp54]]|1.93|
|[[:results:exp501|Methotrexate 0.01μM R08 exp501]]|1.95|
|[[:results:exp418|Tunicamycin 0.04μM R07 exp418]]|2.16|
|[[:results:exp493|IL-3 9ng/ml R08 exp493]]|2.19|
|[[:results:exp307|Rapamycin 2μM plus Cyclosporin-A 3μM R07 exp307]]|2.24|
|[[:results:exp347|Cyclosporin-A 0.8μM R07 exp347]]|2.26|
|[[:results:exp438|NN-Diethyl-meta-toluamide 500μM R08 exp438]]|2.27|
|[[:results:exp61|YM155 0.0002μM R01 exp61]]|2.32|
|[[:results:exp534|Trientine 500μM R08 exp534]]|2.35|
|[[:results:exp332|Adefovir 20μM R07 exp332]]|2.36|
|[[:results:exp58|UM131593 0.1μM R01 exp58]]|2.64|
|[[:results:exp419|Tunicamycin 0.04 to 0.075μM  on day4 R07 exp419]]|2.88|
|[[:results:exp182|IU1-47 25μM R04 exp182]]|2.94|
|[[:results:exp60|Vinblastine 0.002μM R01 exp60]]|3.94|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:g:golga6l1|GOLGA6L1]]|0.547|
|[[:human genes:p:polr2j3|POLR2J3]]|0.51|
|[[:human genes:t:tceb3c|TCEB3C]]|0.502|
|[[:human genes:t:tceb3cl|TCEB3CL]]|0.492|
|[[:human genes:k:krt78|KRT78]]|0.478|
|[[:human genes:o:orc6|ORC6]]|0.471|
|[[:human genes:t:ticrr|TICRR]]|0.471|
|[[:human genes:t:tceb3cl2|TCEB3CL2]]|0.469|
|[[:human genes:e:ebna1bp2|EBNA1BP2]]|0.46|
|[[:human genes:r:rpl35|RPL35]]|0.457|
|[[:human genes:c:cox7a2l|COX7A2L]]|0.452|
|[[:human genes:p:pole|POLE]]|0.448|
|[[:human genes:c:c14orf93|C14orf93]]|0.443|
|[[:human genes:s:sart1|SART1]]|0.439|
|[[:human genes:p:prim1|PRIM1]]|0.438|
|[[:human genes:r:rps3a|RPS3A]]|0.436|
|[[:human genes:c:c1qtnf9b|C1QTNF9B]]|0.434|
|[[:human genes:p:pola2|POLA2]]|0.433|
|[[:human genes:c:cdca3|CDCA3]]|0.433|
|[[:human genes:s:ssh2|SSH2]]|0.431|
|[[:human genes:p:psmd3|PSMD3]]|0.429|
|[[:human genes:s:slc7a6os|SLC7A6OS]]|0.428|
|[[:human genes:s:slc6a17|SLC6A17]]|0.428|
|[[:human genes:r:rpp40|RPP40]]|0.427|
|[[:human genes:r:rps19|RPS19]]|0.42|
|[[:human genes:s:slc4a1|SLC4A1]]|0.42|
|[[:human genes:t:tbc1d3f|TBC1D3F]]|0.416|
|[[:human genes:c:col2a1|COL2A1]]|0.415|
|[[:human genes:u:upf1|UPF1]]|0.414|
|[[:human genes:c:clcn6|CLCN6]]|0.414|
|[[:human genes:p:psmb2|PSMB2]]|0.41|
|[[:human genes:c:col25a1|COL25A1]]|0.409|
|[[:human genes:t:twistnb|TWISTNB]]|0.407|
|[[:human genes:m:mfsd12|MFSD12]]|0.406|
|[[:human genes:s:supt5h|SUPT5H]]|0.403|
|[[:human genes:m:mcoln1|MCOLN1]]|0.403|
|[[:human genes:t:tbc1d3c|TBC1D3C]]|0.403|
|[[:human genes:a:ankle2|ANKLE2]]|0.402|
|[[:human genes:c:cdh24|CDH24]]|0.401|
|[[:human genes:c:chd4|CHD4]]|0.401|
|[[:human genes:t:tsg101|TSG101]]|0.401|
|[[:human genes:p:pwp2|PWP2]]|0.401|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 344/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|1/1|
|bile duct|10/28|
|blood|12/28|
|bone|6/26|
|breast|12/33|
|central nervous system|28/56|
|cervix|2/4|
|colorectal|6/17|
|esophagus|6/13|
|fibroblast|0/1|
|gastric|4/16|
|kidney|12/21|
|liver|8/20|
|lung|39/75|
|lymphocyte|10/16|
|ovary|13/26|
|pancreas|12/24|
|peripheral nervous system|5/16|
|plasma cell|6/15|
|prostate|0/1|
|skin|19/24|
|soft tissue|6/9|
|thyroid|0/2|
|upper aerodigestive|7/22|
|urinary tract|16/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 929
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.43 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='MPHOSPH10 Expression in NALM6 Cells: 6.43'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>