MPHOSPH10

Entrez Summary: N/A
UniProt Summary: Component of the 60-80S U3 small nucleolar ribonucleoprotein (U3 snoRNP). Required for the early cleavages during pre-18S ribosomal RNA processing.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Rotenone 20μM R00 exp34	-3.07
BI-2536 0.02μM R03 exp96	-2.7
Hinokiflavone 12μM R08 exp487	-2.19
DABN racemic mixture R03 exp93	-1.86
OICR-9429 10μM R03 exp142	-1.86
Pimelic-diphenylamide-106 5μM R00 exp28	-1.84
JQ1 0.8μM R08 exp435	-1.83
Heregulin-B 44ng/ml R08 exp486	1.74
Tunicamycin 0.04 to 0.125μM on day4 R07 exp420	1.74
Nocodazole 0.02μM R00 exp23	1.75
Docetaxel 0.001 to 0.002μM on day4 R04 exp159	1.79
VE-822 0.04μM R06 exp300	1.8
IWR1 50μM R08 exp495	1.83
Phorbol-12-myristate-13-acetate 0.57μM R08 exp514	1.86
Celastrol 0.12μM R05 exp225	1.89
Taxol 0.002μM R01 exp54	1.93
Methotrexate 0.01μM R08 exp501	1.95
Tunicamycin 0.04μM R07 exp418	2.16
IL-3 9ng/ml R08 exp493	2.19
Rapamycin 2μM plus Cyclosporin-A 3μM R07 exp307	2.24
Cyclosporin-A 0.8μM R07 exp347	2.26
NN-Diethyl-meta-toluamide 500μM R08 exp438	2.27
YM155 0.0002μM R01 exp61	2.32
Trientine 500μM R08 exp534	2.35
Adefovir 20μM R07 exp332	2.36
UM131593 0.1μM R01 exp58	2.64
Tunicamycin 0.04 to 0.075μM on day4 R07 exp419	2.88
IU1-47 25μM R04 exp182	2.94
Vinblastine 0.002μM R01 exp60	3.94

Global Fraction of Cell Lines Where Essential: 344/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	1/1
bile duct	10/28
blood	12/28
bone	6/26
breast	12/33
central nervous system	28/56
cervix	2/4
colorectal	6/17
esophagus	6/13
fibroblast	0/1
gastric	4/16
kidney	12/21
liver	8/20
lung	39/75
lymphocyte	10/16
ovary	13/26
pancreas	12/24
peripheral nervous system	5/16
plasma cell	6/15
prostate	0/1
skin	19/24
soft tissue	6/9
thyroid	0/2
upper aerodigestive	7/22
urinary tract	16/29
uterus	0/5

Expression Distribution

Mpp10 complex
small nucleolar ribonucleoprotein complex
small-subunit processome
negative regulation of phosphatase activity
negative regulation of dephosphorylation
chromosome
regulation of phosphatase activity
regulation of dephosphorylation
rRNA processing
rRNA metabolic process
ribosome biogenesis
RNA splicing, via transesterification reactions
ncRNA processing
RNA splicing
negative regulation of hydrolase activity
ribonucleoprotein complex biogenesis
ncRNA metabolic process
negative regulation of phosphate metabolic process
negative regulation of phosphorus metabolic process
negative regulation of catalytic activity
nucleolus
RNA processing
negative regulation of molecular function
regulation of hydrolase activity
RNA binding
RNA metabolic process
regulation of phosphate metabolic process
regulation of phosphorus metabolic process
gene expression