MPP1

Entrez Summary: This gene encodes the prototype of the membrane-associated guanylate kinase (MAGUK) family proteins. MAGUKs interact with the cytoskeleton and regulate cell proliferation, signaling pathways, and intercellular junctions. The encoded protein is an extensively palmitoylated membrane phosphoprotein containing a PDZ domain, a Src homology 3 (SH3) motif, and a guanylate kinase domain. This gene product interacts with various cytoskeletal proteins and cell junctional proteins in different tissue and cell types, and may be involved in the regulation of cell shape, hair cell development, neural patterning of the retina, and apico-basal polarity and tumor suppression pathways in non-erythroid cells. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2009].
UniProt Summary: Essential regulator of neutrophil polarity. Regulates neutrophil polarization by regulating AKT1 phosphorylation through a mechanism that is independent of PIK3CG activity (By similarity). {ECO:0000250}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/694

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/26
bone	0/26
breast	0/30
central nervous system	0/49
cervix	0/4
colorectal	0/17
esophagus	0/11
fibroblast	0/1
gastric	0/14
kidney	0/18
liver	0/19
lung	0/72
lymphocyte	0/16
ovary	0/25
pancreas	0/22
peripheral nervous system	0/15
plasma cell	0/12
prostate	0/1
skin	0/20
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/28
uterus	0/5

Expression Distribution

guanylate kinase activity
GDP metabolic process
GMP metabolic process
cortical cytoskeleton
regulation of neutrophil chemotaxis
stereocilium
regulation of neutrophil migration
purine ribonucleoside monophosphate metabolic process
purine nucleoside monophosphate metabolic process
guanosine-containing compound metabolic process
regulation of granulocyte chemotaxis
ribonucleoside monophosphate metabolic process
purine ribonucleoside metabolic process
purine ribonucleoside diphosphate metabolic process
purine nucleoside diphosphate metabolic process
ribonucleoside diphosphate metabolic process
purine nucleoside metabolic process
nucleoside monophosphate metabolic process
ribonucleoside metabolic process
nucleoside diphosphate metabolic process
intracellular
nucleoside metabolic process
regulation of leukocyte chemotaxis
glycosyl compound metabolic process
regulation of leukocyte migration
regulation of chemotaxis
purine ribonucleotide metabolic process
ribonucleotide metabolic process
purine nucleotide metabolic process
ribose phosphate metabolic process
purine-containing compound metabolic process
nuclear speck
nucleotide metabolic process
nucleoside phosphate metabolic process
nucleobase-containing small molecule metabolic process
regulation of cell migration
organophosphate metabolic process
regulation of cell motility
regulation of locomotion
regulation of cellular component movement