MPP7

Entrez Summary: N/A
UniProt Summary: Acts as an important adapter that promotes epithelial cell polarity and tight junction formation via its interaction with DLG1. Involved in the assembly of protein complexes at sites of cell-cell contact. {ECO:0000269|PubMed:17332497}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

protein localization to adherens junction
MPP7-DLG1-LIN7 complex
protein localization to cell junction
signaling adaptor activity
bicellular tight junction assembly
tight junction assembly
tight junction organization
apical junction assembly
molecular adaptor activity
adherens junction
cell-cell junction assembly
establishment of cell polarity
bicellular tight junction
cell-cell junction organization
cell junction assembly
establishment or maintenance of cell polarity
cell junction organization
protein domain specific binding
positive regulation of protein complex assembly
cadherin binding
regulation of protein complex assembly
protein heterodimerization activity
positive regulation of cellular component biogenesis
cell junction
regulation of cellular component biogenesis
positive regulation of cellular component organization
positive regulation of signal transduction
positive regulation of cell communication
positive regulation of signaling