MRAP [The Human Chemical-Genetic Interaction Map Project]

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======= MRAP =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: MRAP
  * **<color #00a2e8>Official Name</color>**: melanocortin 2 receptor accessory protein
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=56246|56246]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q8TCY5|Q8TCY5]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=MRAP&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20MRAP|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/609196|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a melanocortin receptor-interacting protein. The encoded protein regulates trafficking and function of the melanocortin 2 receptor in the adrenal gland. The encoded protein can also modulate signaling of other melanocortin receptors. Mutations in this gene have been associated with familial glucocorticoid deficiency type 2. Alternatively spliced transcript variants have been described. [provided by RefSeq, Dec 2009]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Modulator of melanocortin receptors (MC1R, MC2R, MC3R, MC4R and MC5R). Acts by increasing ligand-sensitivity of melanocortin receptors and enhancing generation of cAMP by the receptors. Required both for MC2R trafficking to the cell surface of adrenal cells and for signaling in response to corticotropin (ACTH). May be involved in the intracellular trafficking pathways in adipocyte cells. {ECO:0000269|PubMed:15654338, ECO:0000269|PubMed:19329486, ECO:0000269|PubMed:20371771}.

<button type='default' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
No Pfam Domain information is available for this gene.
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|type 5 melanocortin receptor binding|
|corticotropin hormone receptor binding|
|type 1 melanocortin receptor binding|
|type 3 melanocortin receptor binding|
|type 4 melanocortin receptor binding|
|positive regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway|
|negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway|
|regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway|
|negative regulation of protein localization to plasma membrane|
|positive regulation of cAMP-mediated signaling|
|negative regulation of cAMP-mediated signaling|
|negative regulation of protein localization to cell periphery|
|positive regulation of G protein-coupled receptor signaling pathway|
|negative regulation of protein localization to membrane|
|negative regulation of G protein-coupled receptor signaling pathway|
|regulation of cAMP-mediated signaling|
|regulation of protein localization to plasma membrane|
|negative regulation of cellular protein localization|
|regulation of protein localization to cell periphery|
|regulation of G protein-coupled receptor signaling pathway|
|protein localization to plasma membrane|
|regulation of protein localization to membrane|
|protein localization to cell periphery|
|protein localization to membrane|
|negative regulation of intracellular signal transduction|
|regulation of cellular protein localization|
|regulation of cellular localization|
|endoplasmic reticulum membrane|
|endoplasmic reticulum|
|positive regulation of intracellular signal transduction|
|regulation of protein localization|
|identical protein binding|
|negative regulation of signal transduction|
|negative regulation of cell communication|
|negative regulation of signaling|
|cellular protein localization|
|cellular macromolecule localization|
|negative regulation of response to stimulus|
|positive regulation of signal transduction|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of intracellular signal transduction|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp504|MK2206 4μM R08 exp504]]|-1.74|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:h:hgc6.3|HGC6.3]]|0.422|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 14677
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 1.4 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='MRAP Expression in NALM6 Cells: 1.4'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>