MRAP

Gene Information

Official Symbol: MRAP
Official Name: melanocortin 2 receptor accessory protein
Aliases and Previous Symbols: N/A
Entrez ID: 56246
UniProt: Q8TCY5
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: This gene encodes a melanocortin receptor-interacting protein. The encoded protein regulates trafficking and function of the melanocortin 2 receptor in the adrenal gland. The encoded protein can also modulate signaling of other melanocortin receptors. Mutations in this gene have been associated with familial glucocorticoid deficiency type 2. Alternatively spliced transcript variants have been described. [provided by RefSeq, Dec 2009].
UniProt Summary: Modulator of melanocortin receptors (MC1R, MC2R, MC3R, MC4R and MC5R). Acts by increasing ligand-sensitivity of melanocortin receptors and enhancing generation of cAMP by the receptors. Required both for MC2R trafficking to the cell surface of adrenal cells and for signaling in response to corticotropin (ACTH). May be involved in the intracellular trafficking pathways in adipocyte cells. {ECO:0000269|PubMed:15654338, ECO:0000269|PubMed:19329486, ECO:0000269|PubMed:20371771}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 14677
Expression level (log2 read counts): 1.4

Expression Distribution

type 5 melanocortin receptor binding
corticotropin hormone receptor binding
type 1 melanocortin receptor binding
type 3 melanocortin receptor binding
type 4 melanocortin receptor binding
positive regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway
negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway
regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway
negative regulation of protein localization to plasma membrane
positive regulation of cAMP-mediated signaling
negative regulation of cAMP-mediated signaling
negative regulation of protein localization to cell periphery
positive regulation of G protein-coupled receptor signaling pathway
negative regulation of protein localization to membrane
negative regulation of G protein-coupled receptor signaling pathway
regulation of cAMP-mediated signaling
regulation of protein localization to plasma membrane
negative regulation of cellular protein localization
regulation of protein localization to cell periphery
regulation of G protein-coupled receptor signaling pathway
protein localization to plasma membrane
regulation of protein localization to membrane
protein localization to cell periphery
protein localization to membrane
negative regulation of intracellular signal transduction
regulation of cellular protein localization
regulation of cellular localization
endoplasmic reticulum membrane
endoplasmic reticulum
positive regulation of intracellular signal transduction
regulation of protein localization
identical protein binding
negative regulation of signal transduction
negative regulation of cell communication
negative regulation of signaling
cellular protein localization
cellular macromolecule localization
negative regulation of response to stimulus
positive regulation of signal transduction
positive regulation of cell communication