MRAS

Entrez Summary: N/A
UniProt Summary: May serve as an important signal transducer for a novel upstream stimuli in controlling cell proliferation. Weakly activates the MAP kinase pathway. {ECO:0000269|PubMed:16630891}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Screen	Score
Rotenone 0.07μM R08 exp431	-1.87
BVD-523 15μM R02 exp67	2.37

GTP-dependent protein binding
GDP binding
response to leukemia inhibitory factor
cellular response to leukemia inhibitory factor
Ras protein signal transduction
muscle organ development
small GTPase mediated signal transduction
GTPase activity
GTP binding
muscle structure development
actin cytoskeleton organization
actin filament-based process
cellular response to cytokine stimulus
response to cytokine
cytoskeleton organization
intracellular signal transduction