MRP63 [The Human Chemical-Genetic Interaction Map Project]

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======= MRP63 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: MRPL57
  * **<color #00a2e8>Official Name</color>**: mitochondrial ribosomal protein L57
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=78988|78988]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9BQC6|Q9BQC6]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=MRP63&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20MRP63|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/611997|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='default' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
No Pfam Domain information is available for this gene.
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|mitochondrial ribosome|
|mitochondrial large ribosomal subunit|
|mitochondrial translational elongation|
|mitochondrial translational termination|
|translational termination|
|mitochondrial translation|
|translational elongation|
|cellular protein complex disassembly|
|mitochondrial gene expression|
|structural constituent of ribosome|
|protein-containing complex disassembly|
|translation|
|mitochondrial inner membrane|
|cellular component disassembly|
|peptide biosynthetic process|
|amide biosynthetic process|
|peptide metabolic process|
|cellular amide metabolic process|
|mitochondrion|
|organonitrogen compound biosynthetic process|
|cellular nitrogen compound biosynthetic process|
|cellular macromolecule biosynthetic process|
|macromolecule biosynthetic process|
|protein-containing complex subunit organization|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp185|L-BMAA 500 to 750μM on day4 R04 exp185]]|-1.7|
|[[:results:exp474|CR131-b 0.005μM R08 exp474]]|1.72|
|[[:results:exp451|Atovaquone 15μM R08 exp451]]|1.77|
|[[:results:exp34|Rotenone 20μM R00 exp34]]|1.79|
|[[:results:exp329|Hydroxyurea 100μM R07 exp329]]|1.82|
|[[:results:exp66|BI-D1870 3.15μM R02 exp66]]|1.91|
|[[:results:exp440|Aphidicolin 0.4μM R08 exp440]]|2|
|[[:results:exp68|Clomiphene 4.4μM R02 exp68]]|2.02|
|[[:results:exp472|CI-1040 9.5μM R08 exp472]]|2.11|
|[[:results:exp434|Vemurafenib 6.6μM R08 exp434]]|2.13|
|[[:results:exp84|UM0125461 0.74μM R02 exp84]]|2.16|
|[[:results:exp25|Oligomycin-A 2μM R00 exp25]]|2.17|
|[[:results:exp290|LLY-283 2.6μM R06 exp290]]|2.27|
|[[:results:exp515|PU-H71 1μM R08 exp515]]|2.27|
|[[:results:exp441|GSK-J4 1.5μM R08 exp441]]|2.72|
|[[:results:exp211|AICAR 240μM R05 exp211]]|3|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:h:hsd17b10|HSD17B10]]|0.728|
|[[:human genes:d:dap3|DAP3]]|0.71|
|[[:human genes:m:mrpl21|MRPL21]]|0.705|
|[[:human genes:s:supv3l1|SUPV3L1]]|0.699|
|[[:human genes:m:mrpl23|MRPL23]]|0.692|
|[[:human genes:d:dars2|DARS2]]|0.688|
|[[:human genes:y:yars2|YARS2]]|0.671|
|[[:human genes:m:mrpl53|MRPL53]]|0.668|
|[[:human genes:m:mrps9|MRPS9]]|0.666|
|[[:human genes:m:mrps6|MRPS6]]|0.663|
|[[:human genes:v:vars2|VARS2]]|0.663|
|[[:human genes:g:gfm1|GFM1]]|0.661|
|[[:human genes:m:mrps26|MRPS26]]|0.653|
|[[:human genes:m:mrps14|MRPS14]]|0.653|
|[[:human genes:m:mrps34|MRPS34]]|0.65|
|[[:human genes:m:mrps5|MRPS5]]|0.644|
|[[:human genes:m:mrps21|MRPS21]]|0.644|
|[[:human genes:n:ndufa3|NDUFA3]]|0.642|
|[[:human genes:t:tars2|TARS2]]|0.64|
|[[:human genes:m:mrps18a|MRPS18A]]|0.636|
|[[:human genes:r:rpusd4|RPUSD4]]|0.636|
|[[:human genes:s:sars2|SARS2]]|0.631|
|[[:human genes:m:mrps16|MRPS16]]|0.63|
|[[:human genes:m:mrps23|MRPS23]]|0.63|
|[[:human genes:m:mrps25|MRPS25]]|0.63|
|[[:human genes:n:nars2|NARS2]]|0.629|
|[[:human genes:c:cox16|COX16]]|0.626|
|[[:human genes:q:qrsl1|QRSL1]]|0.625|
|[[:human genes:s:selrc1|SELRC1]]|0.622|
|[[:human genes:t:tfam|TFAM]]|0.619|
|[[:human genes:s:sco2|SCO2]]|0.614|
|[[:human genes:t:trub2|TRUB2]]|0.613|
|[[:human genes:m:mrpl45|MRPL45]]|0.612|
|[[:human genes:p:pnpt1|PNPT1]]|0.611|
|[[:human genes:p:pars2|PARS2]]|0.611|
|[[:human genes:c:c12orf65|C12orf65]]|0.607|
|[[:human genes:m:mrpl47|MRPL47]]|0.605|
|[[:human genes:b:bcs1l|BCS1L]]|0.604|
|[[:human genes:w:wbscr16|WBSCR16]]|0.603|
|[[:human genes:m:mars2|MARS2]]|0.6|
|[[:human genes:r:rars2|RARS2]]|0.599|
|[[:human genes:m:mrpl3|MRPL3]]|0.598|
|[[:human genes:n:ndufaf7|NDUFAF7]]|0.596|
|[[:human genes:c:c10orf2|C10orf2]]|0.595|
|[[:human genes:n:ndufa1|NDUFA1]]|0.595|
|[[:human genes:m:mrpl44|MRPL44]]|0.592|
|[[:human genes:t:tufm|TUFM]]|0.591|
|[[:human genes:f:fastkd5|FASTKD5]]|0.588|
|[[:human genes:m:mtrf1l|MTRF1L]]|0.588|
|[[:human genes:m:mrpl12|MRPL12]]|0.588|
|[[:human genes:f:fars2|FARS2]]|0.588|
|[[:human genes:m:mrpl42|MRPL42]]|0.587|
|[[:human genes:m:mtg2|MTG2]]|0.587|
|[[:human genes:m:mrpl15|MRPL15]]|0.587|
|[[:human genes:m:mrpl20|MRPL20]]|0.586|
|[[:human genes:n:ndufb11|NDUFB11]]|0.585|
|[[:human genes:e:ears2|EARS2]]|0.584|
|[[:human genes:r:rbfa|RBFA]]|0.582|
|[[:human genes:a:aifm1|AIFM1]]|0.577|
|[[:human genes:g:gtpbp10|GTPBP10]]|0.576|
|[[:human genes:m:mrps24|MRPS24]]|0.575|
|[[:human genes:s:slc25a26|SLC25A26]]|0.572|
|[[:human genes:m:mrps12|MRPS12]]|0.566|
|[[:human genes:l:lars2|LARS2]]|0.565|
|[[:human genes:t:tefm|TEFM]]|0.565|
|[[:human genes:f:ftsj2|FTSJ2]]|0.562|
|[[:human genes:n:ndufc2|NDUFC2]]|0.56|
|[[:human genes:r:rnaseh1|RNASEH1]]|0.557|
|[[:human genes:c:cox7b|COX7B]]|0.557|
|[[:human genes:m:mrps2|MRPS2]]|0.557|
|[[:human genes:n:ndufv1|NDUFV1]]|0.551|
|[[:human genes:e:elac2|ELAC2]]|0.551|
|[[:human genes:m:mtpap|MTPAP]]|0.544|
|[[:human genes:h:hars2|HARS2]]|0.544|
|[[:human genes:m:mrps10|MRPS10]]|0.543|
|[[:human genes:m:mrpl33|MRPL33]]|0.543|
|[[:human genes:k:kiaa0391|KIAA0391]]|0.541|
|[[:human genes:g:gfm2|GFM2]]|0.54|
|[[:human genes:u:uqcrc2|UQCRC2]]|0.539|
|[[:human genes:p:polrmt|POLRMT]]|0.536|
|[[:human genes:m:mrps33|MRPS33]]|0.536|
|[[:human genes:c:chchd4|CHCHD4]]|0.532|
|[[:human genes:n:ndufs2|NDUFS2]]|0.529|
|[[:human genes:p:pdss1|PDSS1]]|0.529|
|[[:human genes:a:aars2|AARS2]]|0.525|
|[[:human genes:t:tomm20|TOMM20]]|0.525|
|[[:human genes:m:mrpl39|MRPL39]]|0.525|
|[[:human genes:m:mrpl55|MRPL55]]|0.523|
|[[:human genes:r:rtn4ip1|RTN4IP1]]|0.519|
|[[:human genes:p:pet112|PET112]]|0.516|
|[[:human genes:c:coa3|COA3]]|0.515|
|[[:human genes:m:mrps7|MRPS7]]|0.512|
|[[:human genes:c:coq2|COQ2]]|0.51|
|[[:human genes:g:gatc|GATC]]|0.508|
|[[:human genes:n:ndufaf3|NDUFAF3]]|0.507|
|[[:human genes:a:atp5c1|ATP5C1]]|0.506|
|[[:human genes:n:ndufs7|NDUFS7]]|0.505|
|[[:human genes:a:atp5a1|ATP5A1]]|0.504|
|[[:human genes:u:uqcr10|UQCR10]]|0.503|
|[[:human genes:c:chchd1|CHCHD1]]|0.501|
|[[:human genes:p:ptcd3|PTCD3]]|0.499|
|[[:human genes:m:mrpl41|MRPL41]]|0.498|
|[[:human genes:m:mrpl13|MRPL13]]|0.498|
|[[:human genes:r:rnmtl1|RNMTL1]]|0.497|
|[[:human genes:m:mrps11|MRPS11]]|0.497|
|[[:human genes:m:mrpl43|MRPL43]]|0.497|
|[[:human genes:a:atp5d|ATP5D]]|0.497|
|[[:human genes:c:coa6|COA6]]|0.496|
|[[:human genes:r:rpusd3|RPUSD3]]|0.496|
|[[:human genes:t:tfb1m|TFB1M]]|0.495|
|[[:human genes:c:cox6c|COX6C]]|0.495|
|[[:human genes:t:tmem242|TMEM242]]|0.492|
|[[:human genes:p:pet117|PET117]]|0.49|
|[[:human genes:p:polg2|POLG2]]|0.489|
|[[:human genes:c:cars2|CARS2]]|0.489|
|[[:human genes:m:mrpl27|MRPL27]]|0.488|
|[[:human genes:a:atp5j|ATP5J]]|0.485|
|[[:human genes:n:ndufa11|NDUFA11]]|0.485|
|[[:human genes:c:cox6b1|COX6B1]]|0.485|
|[[:human genes:g:gtpbp6|GTPBP6]]|0.485|
|[[:human genes:t:timmdc1|TIMMDC1]]|0.484|
|[[:human genes:c:cox15|COX15]]|0.483|
|[[:human genes:m:mrpl52|MRPL52]]|0.482|
|[[:human genes:t:tomm40|TOMM40]]|0.482|
|[[:human genes:m:mrpl34|MRPL34]]|0.482|
|[[:human genes:n:ndufb9|NDUFB9]]|0.481|
|[[:human genes:a:atp5sl|ATP5SL]]|0.479|
|[[:human genes:m:mrpl18|MRPL18]]|0.479|
|[[:human genes:n:ndufb6|NDUFB6]]|0.477|
|[[:human genes:n:ndufb5|NDUFB5]]|0.476|
|[[:human genes:w:wars2|WARS2]]|0.475|
|[[:human genes:m:mrps27|MRPS27]]|0.474|
|[[:human genes:c:coq4|COQ4]]|0.474|
|[[:human genes:n:ndufb1|NDUFB1]]|0.474|
|[[:human genes:c:c17orf89|C17orf89]]|0.474|
|[[:human genes:n:ndufaf4|NDUFAF4]]|0.472|
|[[:human genes:m:mettl17|METTL17]]|0.472|
|[[:human genes:n:ndufa2|NDUFA2]]|0.472|
|[[:human genes:l:lrpprc|LRPPRC]]|0.471|
|[[:human genes:c:coq3|COQ3]]|0.47|
|[[:human genes:m:mrps22|MRPS22]]|0.47|
|[[:human genes:d:dhrsx|DHRSX]]|0.47|
|[[:human genes:m:mrps35|MRPS35]]|0.469|
|[[:human genes:m:mrpl38|MRPL38]]|0.468|
|[[:human genes:n:ndufb7|NDUFB7]]|0.468|
|[[:human genes:a:atp5b|ATP5B]]|0.467|
|[[:human genes:m:mrpl4|MRPL4]]|0.466|
|[[:human genes:m:mterfd2|MTERFD2]]|0.466|
|[[:human genes:t:trmt10c|TRMT10C]]|0.466|
|[[:human genes:m:mrpl46|MRPL46]]|0.466|
|[[:human genes:m:mrpl17|MRPL17]]|0.466|
|[[:human genes:m:mterfd1|MTERFD1]]|0.465|
|[[:human genes:p:polg|POLG]]|0.465|
|[[:human genes:t:triap1|TRIAP1]]|0.465|
|[[:human genes:m:mrpl49|MRPL49]]|0.463|
|[[:human genes:a:aasdhppt|AASDHPPT]]|0.463|
|[[:human genes:c:cox17|COX17]]|0.463|
|[[:human genes:m:mrpl32|MRPL32]]|0.461|
|[[:human genes:c:coa5|COA5]]|0.461|
|[[:human genes:h:hccs|HCCS]]|0.46|
|[[:human genes:f:fh|FH]]|0.46|
|[[:human genes:i:iba57|IBA57]]|0.459|
|[[:human genes:c:coq7|COQ7]]|0.459|
|[[:human genes:p:ppa2|PPA2]]|0.458|
|[[:human genes:m:mrpl11|MRPL11]]|0.458|
|[[:human genes:m:mipep|MIPEP]]|0.458|
|[[:human genes:a:acad9|ACAD9]]|0.457|
|[[:human genes:m:mrpl36|MRPL36]]|0.457|
|[[:human genes:s:ssbp1|SSBP1]]|0.456|
|[[:human genes:m:mrpl22|MRPL22]]|0.455|
|[[:human genes:n:ndufs5|NDUFS5]]|0.454|
|[[:human genes:c:clpp|CLPP]]|0.454|
|[[:human genes:h:higd2a|HIGD2A]]|0.452|
|[[:human genes:t:timm8b|TIMM8B]]|0.452|
|[[:human genes:m:mrpl28|MRPL28]]|0.449|
|[[:human genes:m:mrpl9|MRPL9]]|0.449|
|[[:human genes:m:mtg1|MTG1]]|0.448|
|[[:human genes:e:ecsit|ECSIT]]|0.447|
|[[:human genes:m:mtif3|MTIF3]]|0.445|
|[[:human genes:t:tomm7|TOMM7]]|0.445|
|[[:human genes:n:nfu1|NFU1]]|0.444|
|[[:human genes:n:ndufaf5|NDUFAF5]]|0.443|
|[[:human genes:n:ndufb4|NDUFB4]]|0.442|
|[[:human genes:a:atp5o|ATP5O]]|0.44|
|[[:human genes:n:ndufb3|NDUFB3]]|0.439|
|[[:human genes:p:pgm3|PGM3]]|0.438|
|[[:human genes:a:atp5e|ATP5E]]|0.438|
|[[:human genes:t:tmem126b|TMEM126B]]|0.437|
|[[:human genes:t:tomm22|TOMM22]]|0.437|
|[[:human genes:h:hmgxb3|HMGXB3]]|0.436|
|[[:human genes:c:cox19|COX19]]|0.436|
|[[:human genes:m:mrpl35|MRPL35]]|0.436|
|[[:human genes:f:fastkd2|FASTKD2]]|0.435|
|[[:human genes:c:crls1|CRLS1]]|0.433|
|[[:human genes:s:sco1|SCO1]]|0.433|
|[[:human genes:o:opa1|OPA1]]|0.428|
|[[:human genes:c:cycs|CYCS]]|0.428|
|[[:human genes:d:ddx28|DDX28]]|0.426|
|[[:human genes:d:dhx30|DHX30]]|0.424|
|[[:human genes:c:coq6|COQ6]]|0.423|
|[[:human genes:d:dolk|DOLK]]|0.423|
|[[:human genes:d:dnlz|DNLZ]]|0.422|
|[[:human genes:a:atp5h|ATP5H]]|0.422|
|[[:human genes:n:noa1|NOA1]]|0.422|
|[[:human genes:n:ndufc1|NDUFC1]]|0.422|
|[[:human genes:g:grsf1|GRSF1]]|0.421|
|[[:human genes:m:mrps17|MRPS17]]|0.42|
|[[:human genes:n:ndufaf6|NDUFAF6]]|0.419|
|[[:human genes:m:malsu1|MALSU1]]|0.418|
|[[:human genes:t:tmem261|TMEM261]]|0.417|
|[[:human genes:c:cox11|COX11]]|0.415|
|[[:human genes:n:nubpl|NUBPL]]|0.415|
|[[:human genes:f:foxred1|FOXRED1]]|0.415|
|[[:human genes:n:ndufa13|NDUFA13]]|0.414|
|[[:human genes:a:alg6|ALG6]]|0.413|
|[[:human genes:n:ndufs1|NDUFS1]]|0.412|
|[[:human genes:s:ssb|SSB]]|0.412|
|[[:human genes:a:aldh18a1|ALDH18A1]]|0.412|
|[[:human genes:g:gars|GARS]]|0.41|
|[[:human genes:t:tfb2m|TFB2M]]|0.41|
|[[:human genes:m:mrpl37|MRPL37]]|0.409|
|[[:human genes:c:c1qbp|C1QBP]]|0.409|
|[[:human genes:e:eral1|ERAL1]]|0.408|
|[[:human genes:s:slc25a19|SLC25A19]]|0.405|
|[[:human genes:f:fastkd1|FASTKD1]]|0.404|
|[[:human genes:m:mtif2|MTIF2]]|0.402|
|[[:human genes:c:cox20|COX20]]|0.402|
|[[:human genes:g:gtf3c6|GTF3C6]]|0.402|
|[[:human genes:p:ppcs|PPCS]]|0.401|
|[[:human genes:t:timm17a|TIMM17A]]|0.401|
|[[:human genes:m:mrps18b|MRPS18B]]|0.4|
|[[:human genes:g:gtpbp8|GTPBP8]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 389/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|1/1|
|bile duct|14/28|
|blood|13/28|
|bone|14/26|
|breast|20/33|
|central nervous system|23/56|
|cervix|4/4|
|colorectal|10/17|
|esophagus|12/13|
|fibroblast|0/1|
|gastric|11/16|
|kidney|9/21|
|liver|13/20|
|lung|49/75|
|lymphocyte|5/16|
|ovary|6/26|
|pancreas|8/24|
|peripheral nervous system|5/16|
|plasma cell|7/15|
|prostate|0/1|
|skin|11/24|
|soft tissue|5/9|
|thyroid|0/2|
|upper aerodigestive|15/22|
|urinary tract|19/29|
|uterus|3/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 172
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.2 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='MRP63 Expression in NALM6 Cells: 5.2'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>