MRP63

Gene Information

Official Symbol: MRPL57
Official Name: mitochondrial ribosomal protein L57
Aliases and Previous Symbols: N/A
Entrez ID: 78988
UniProt: Q9BQC6
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: N/A

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
L-BMAA 500 to 750μM on day4 R04 exp185	-1.7
CR131-b 0.005μM R08 exp474	1.72
Atovaquone 15μM R08 exp451	1.77
Rotenone 20μM R00 exp34	1.79
Hydroxyurea 100μM R07 exp329	1.82
BI-D1870 3.15μM R02 exp66	1.91
Aphidicolin 0.4μM R08 exp440	2
Clomiphene 4.4μM R02 exp68	2.02
CI-1040 9.5μM R08 exp472	2.11
Vemurafenib 6.6μM R08 exp434	2.13
UM0125461 0.74μM R02 exp84	2.16
Oligomycin-A 2μM R00 exp25	2.17
LLY-283 2.6μM R06 exp290	2.27
PU-H71 1μM R08 exp515	2.27
GSK-J4 1.5μM R08 exp441	2.72
AICAR 240μM R05 exp211	3

Gene	Correlation
HSD17B10	0.728
DAP3	0.71
MRPL21	0.705
SUPV3L1	0.699
MRPL23	0.692
DARS2	0.688
YARS2	0.671
MRPL53	0.668
MRPS9	0.666
MRPS6	0.663
VARS2	0.663
GFM1	0.661
MRPS26	0.653
MRPS14	0.653
MRPS34	0.65
MRPS5	0.644
MRPS21	0.644
NDUFA3	0.642
TARS2	0.64
MRPS18A	0.636
RPUSD4	0.636
SARS2	0.631
MRPS16	0.63
MRPS23	0.63
MRPS25	0.63
NARS2	0.629
COX16	0.626
QRSL1	0.625
SELRC1	0.622
TFAM	0.619
SCO2	0.614
TRUB2	0.613
MRPL45	0.612
PNPT1	0.611
PARS2	0.611
C12orf65	0.607
MRPL47	0.605
BCS1L	0.604
WBSCR16	0.603
MARS2	0.6
RARS2	0.599
MRPL3	0.598
NDUFAF7	0.596
C10orf2	0.595
NDUFA1	0.595
MRPL44	0.592
TUFM	0.591
FASTKD5	0.588
MTRF1L	0.588
MRPL12	0.588
FARS2	0.588
MRPL42	0.587
MTG2	0.587
MRPL15	0.587
MRPL20	0.586
NDUFB11	0.585
EARS2	0.584
RBFA	0.582
AIFM1	0.577
GTPBP10	0.576
MRPS24	0.575
SLC25A26	0.572
MRPS12	0.566
LARS2	0.565
TEFM	0.565
FTSJ2	0.562
NDUFC2	0.56
RNASEH1	0.557
COX7B	0.557
MRPS2	0.557
NDUFV1	0.551
ELAC2	0.551
MTPAP	0.544
HARS2	0.544
MRPS10	0.543
MRPL33	0.543
KIAA0391	0.541
GFM2	0.54
UQCRC2	0.539
POLRMT	0.536
MRPS33	0.536
CHCHD4	0.532
NDUFS2	0.529
PDSS1	0.529
AARS2	0.525
TOMM20	0.525
MRPL39	0.525
MRPL55	0.523
RTN4IP1	0.519
PET112	0.516
COA3	0.515
MRPS7	0.512
COQ2	0.51
GATC	0.508
NDUFAF3	0.507
ATP5C1	0.506
NDUFS7	0.505
ATP5A1	0.504
UQCR10	0.503
CHCHD1	0.501
PTCD3	0.499
MRPL41	0.498
MRPL13	0.498
RNMTL1	0.497
MRPS11	0.497
MRPL43	0.497
ATP5D	0.497
COA6	0.496
RPUSD3	0.496
TFB1M	0.495
COX6C	0.495
TMEM242	0.492
PET117	0.49
POLG2	0.489
CARS2	0.489
MRPL27	0.488
ATP5J	0.485
NDUFA11	0.485
COX6B1	0.485
GTPBP6	0.485
TIMMDC1	0.484
COX15	0.483
MRPL52	0.482
TOMM40	0.482
MRPL34	0.482
NDUFB9	0.481
ATP5SL	0.479
MRPL18	0.479
NDUFB6	0.477
NDUFB5	0.476
WARS2	0.475
MRPS27	0.474
COQ4	0.474
NDUFB1	0.474
C17orf89	0.474
NDUFAF4	0.472
METTL17	0.472
NDUFA2	0.472
LRPPRC	0.471
COQ3	0.47
MRPS22	0.47
DHRSX	0.47
MRPS35	0.469
MRPL38	0.468
NDUFB7	0.468
ATP5B	0.467
MRPL4	0.466
MTERFD2	0.466
TRMT10C	0.466
MRPL46	0.466
MRPL17	0.466
MTERFD1	0.465
POLG	0.465
TRIAP1	0.465
MRPL49	0.463
AASDHPPT	0.463
COX17	0.463
MRPL32	0.461
COA5	0.461
HCCS	0.46
FH	0.46
IBA57	0.459
COQ7	0.459
PPA2	0.458
MRPL11	0.458
MIPEP	0.458
ACAD9	0.457
MRPL36	0.457
SSBP1	0.456
MRPL22	0.455
NDUFS5	0.454
CLPP	0.454
HIGD2A	0.452
TIMM8B	0.452
MRPL28	0.449
MRPL9	0.449
MTG1	0.448
ECSIT	0.447
MTIF3	0.445
TOMM7	0.445
NFU1	0.444
NDUFAF5	0.443
NDUFB4	0.442
ATP5O	0.44
NDUFB3	0.439
PGM3	0.438
ATP5E	0.438
TMEM126B	0.437
TOMM22	0.437
HMGXB3	0.436
COX19	0.436
MRPL35	0.436
FASTKD2	0.435
CRLS1	0.433
SCO1	0.433
OPA1	0.428
CYCS	0.428
DDX28	0.426
DHX30	0.424
COQ6	0.423
DOLK	0.423
DNLZ	0.422
ATP5H	0.422
NOA1	0.422
NDUFC1	0.422
GRSF1	0.421
MRPS17	0.42
NDUFAF6	0.419
MALSU1	0.418
TMEM261	0.417
COX11	0.415
NUBPL	0.415
FOXRED1	0.415
NDUFA13	0.414
ALG6	0.413
NDUFS1	0.412
SSB	0.412
ALDH18A1	0.412
GARS	0.41
TFB2M	0.41
MRPL37	0.409
C1QBP	0.409
ERAL1	0.408
SLC25A19	0.405
FASTKD1	0.404
MTIF2	0.402
COX20	0.402
GTF3C6	0.402
PPCS	0.401
TIMM17A	0.401
MRPS18B	0.4
GTPBP8	0.4

Global Fraction of Cell Lines Where Essential: 389/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	1/1
bile duct	14/28
blood	13/28
bone	14/26
breast	20/33
central nervous system	23/56
cervix	4/4
colorectal	10/17
esophagus	12/13
fibroblast	0/1
gastric	11/16
kidney	9/21
liver	13/20
lung	49/75
lymphocyte	5/16
ovary	6/26
pancreas	8/24
peripheral nervous system	5/16
plasma cell	7/15
prostate	0/1
skin	11/24
soft tissue	5/9
thyroid	0/2
upper aerodigestive	15/22
urinary tract	19/29
uterus	3/5

Essentiality in NALM6

Essentiality Rank: 172
Expression level (log2 read counts): 5.2

Expression Distribution

mitochondrial ribosome
mitochondrial large ribosomal subunit
mitochondrial translational elongation
mitochondrial translational termination
translational termination
mitochondrial translation
translational elongation
cellular protein complex disassembly
mitochondrial gene expression
structural constituent of ribosome
protein-containing complex disassembly
translation
mitochondrial inner membrane
cellular component disassembly
peptide biosynthetic process
amide biosynthetic process
peptide metabolic process
cellular amide metabolic process
mitochondrion
organonitrogen compound biosynthetic process
cellular nitrogen compound biosynthetic process
cellular macromolecule biosynthetic process
macromolecule biosynthetic process
protein-containing complex subunit organization
gene expression