MRPL20 [The Human Chemical-Genetic Interaction Map Project]

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======= MRPL20 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: MRPL20
  * **<color #00a2e8>Official Name</color>**: mitochondrial ribosomal protein L20
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=55052|55052]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9BYC9|Q9BYC9]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=MRPL20&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20MRPL20|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/611833|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Ribosomal L20|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|mitochondrial ribosome|
|ribosomal large subunit assembly|
|rRNA binding|
|mitochondrial large ribosomal subunit|
|ribosome assembly|
|ribosomal large subunit biogenesis|
|mitochondrial translational elongation|
|mitochondrial translational termination|
|translational termination|
|mitochondrial translation|
|translational elongation|
|cellular protein complex disassembly|
|mitochondrial gene expression|
|structural constituent of ribosome|
|ribonucleoprotein complex assembly|
|protein-containing complex disassembly|
|ribonucleoprotein complex subunit organization|
|ribosome biogenesis|
|translation|
|mitochondrial inner membrane|
|cellular component disassembly|
|peptide biosynthetic process|
|ribonucleoprotein complex biogenesis|
|amide biosynthetic process|
|peptide metabolic process|
|organelle assembly|
|cellular amide metabolic process|
|cellular protein-containing complex assembly|
|mitochondrion|
|RNA binding|
|organonitrogen compound biosynthetic process|
|protein-containing complex assembly|
|cellular nitrogen compound biosynthetic process|
|cellular macromolecule biosynthetic process|
|macromolecule biosynthetic process|
|protein-containing complex subunit organization|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp440|Aphidicolin 0.4μM R08 exp440]]|1.72|
|[[:results:exp470|Chloroquine 32μM R08 exp470]]|1.83|
|[[:results:exp529|Thimerosal 0.85μM R08 exp529]]|1.85|
|[[:results:exp441|GSK-J4 1.5μM R08 exp441]]|1.87|
|[[:results:exp492|iCRT14 30μM R08 exp492]]|1.88|
|[[:results:exp65|Mubritinib 0.2μM R02 exp65]]|1.9|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:h:hsd17b10|HSD17B10]]|0.635|
|[[:human genes:y:yars2|YARS2]]|0.613|
|[[:human genes:m:mrps34|MRPS34]]|0.603|
|[[:human genes:m:mrps26|MRPS26]]|0.601|
|[[:human genes:d:dap3|DAP3]]|0.597|
|[[:human genes:m:mrps14|MRPS14]]|0.596|
|[[:human genes:r:rpusd4|RPUSD4]]|0.595|
|[[:human genes:m:mrpl21|MRPL21]]|0.595|
|[[:human genes:m:mrpl45|MRPL45]]|0.592|
|[[:human genes:m:mrpl23|MRPL23]]|0.587|
|[[:human genes:m:mrp63|MRP63]]|0.586|
|[[:human genes:v:vars2|VARS2]]|0.586|
|[[:human genes:l:lars2|LARS2]]|0.584|
|[[:human genes:m:mars2|MARS2]]|0.583|
|[[:human genes:n:nars2|NARS2]]|0.583|
|[[:human genes:g:gfm1|GFM1]]|0.578|
|[[:human genes:w:wbscr16|WBSCR16]]|0.573|
|[[:human genes:t:tars2|TARS2]]|0.571|
|[[:human genes:p:pars2|PARS2]]|0.57|
|[[:human genes:c:cox16|COX16]]|0.57|
|[[:human genes:m:mrps5|MRPS5]]|0.569|
|[[:human genes:m:mrps16|MRPS16]]|0.569|
|[[:human genes:d:dars2|DARS2]]|0.566|
|[[:human genes:s:selrc1|SELRC1]]|0.563|
|[[:human genes:e:ears2|EARS2]]|0.562|
|[[:human genes:m:mrps6|MRPS6]]|0.552|
|[[:human genes:m:mrps21|MRPS21]]|0.551|
|[[:human genes:m:mrpl53|MRPL53]]|0.549|
|[[:human genes:r:rars2|RARS2]]|0.549|
|[[:human genes:s:supv3l1|SUPV3L1]]|0.547|
|[[:human genes:f:ftsj2|FTSJ2]]|0.546|
|[[:human genes:t:tefm|TEFM]]|0.54|
|[[:human genes:m:mrpl3|MRPL3]]|0.539|
|[[:human genes:m:mrps2|MRPS2]]|0.537|
|[[:human genes:t:tufm|TUFM]]|0.537|
|[[:human genes:b:bcs1l|BCS1L]]|0.536|
|[[:human genes:p:pnpt1|PNPT1]]|0.535|
|[[:human genes:q:qrsl1|QRSL1]]|0.533|
|[[:human genes:m:mrpl47|MRPL47]]|0.53|
|[[:human genes:m:mrps9|MRPS9]]|0.529|
|[[:human genes:m:mtrf1l|MTRF1L]]|0.525|
|[[:human genes:g:gtpbp10|GTPBP10]]|0.525|
|[[:human genes:g:gfm2|GFM2]]|0.524|
|[[:human genes:n:ndufa3|NDUFA3]]|0.524|
|[[:human genes:n:ndufa1|NDUFA1]]|0.523|
|[[:human genes:s:sco2|SCO2]]|0.522|
|[[:human genes:h:hars2|HARS2]]|0.522|
|[[:human genes:m:mrpl39|MRPL39]]|0.515|
|[[:human genes:c:c12orf65|C12orf65]]|0.51|
|[[:human genes:r:rbfa|RBFA]]|0.507|
|[[:human genes:p:pet112|PET112]]|0.506|
|[[:human genes:m:mrps18a|MRPS18A]]|0.505|
|[[:human genes:c:cox7b|COX7B]]|0.503|
|[[:human genes:k:kiaa0391|KIAA0391]]|0.503|
|[[:human genes:m:mrps24|MRPS24]]|0.502|
|[[:human genes:m:mrps12|MRPS12]]|0.502|
|[[:human genes:a:atp5c1|ATP5C1]]|0.498|
|[[:human genes:f:fastkd5|FASTKD5]]|0.496|
|[[:human genes:m:mrps7|MRPS7]]|0.493|
|[[:human genes:m:mrpl15|MRPL15]]|0.493|
|[[:human genes:m:mrps11|MRPS11]]|0.491|
|[[:human genes:s:sars2|SARS2]]|0.491|
|[[:human genes:m:mrps23|MRPS23]]|0.486|
|[[:human genes:a:aars2|AARS2]]|0.485|
|[[:human genes:n:ndufaf7|NDUFAF7]]|0.484|
|[[:human genes:c:cars2|CARS2]]|0.483|
|[[:human genes:r:rpusd3|RPUSD3]]|0.482|
|[[:human genes:t:trub2|TRUB2]]|0.48|
|[[:human genes:f:fars2|FARS2]]|0.478|
|[[:human genes:s:slc25a26|SLC25A26]]|0.478|
|[[:human genes:m:mrpl18|MRPL18]]|0.477|
|[[:human genes:a:atp5b|ATP5B]]|0.475|
|[[:human genes:t:triap1|TRIAP1]]|0.474|
|[[:human genes:c:coa6|COA6]]|0.474|
|[[:human genes:m:mrps25|MRPS25]]|0.473|
|[[:human genes:m:mtpap|MTPAP]]|0.471|
|[[:human genes:m:mrpl36|MRPL36]]|0.471|
|[[:human genes:m:mtg2|MTG2]]|0.47|
|[[:human genes:c:coa3|COA3]]|0.468|
|[[:human genes:m:mrpl44|MRPL44]]|0.468|
|[[:human genes:n:ndufb11|NDUFB11]]|0.467|
|[[:human genes:m:mrps27|MRPS27]]|0.466|
|[[:human genes:n:ndufc2|NDUFC2]]|0.465|
|[[:human genes:m:mrpl12|MRPL12]]|0.461|
|[[:human genes:c:cox11|COX11]]|0.46|
|[[:human genes:p:pet117|PET117]]|0.46|
|[[:human genes:r:rnaseh1|RNASEH1]]|0.46|
|[[:human genes:a:atp5d|ATP5D]]|0.458|
|[[:human genes:u:uqcrc2|UQCRC2]]|0.458|
|[[:human genes:p:polg|POLG]]|0.457|
|[[:human genes:m:mrps10|MRPS10]]|0.457|
|[[:human genes:m:mtg1|MTG1]]|0.453|
|[[:human genes:m:mrpl43|MRPL43]]|0.45|
|[[:human genes:a:aifm1|AIFM1]]|0.449|
|[[:human genes:a:atp5a1|ATP5A1]]|0.449|
|[[:human genes:m:mterfd1|MTERFD1]]|0.447|
|[[:human genes:s:ssbp1|SSBP1]]|0.446|
|[[:human genes:c:clpp|CLPP]]|0.445|
|[[:human genes:m:mrpl11|MRPL11]]|0.444|
|[[:human genes:p:polrmt|POLRMT]]|0.444|
|[[:human genes:s:ssb|SSB]]|0.444|
|[[:human genes:s:slc25a3|SLC25A3]]|0.443|
|[[:human genes:m:mrps22|MRPS22]]|0.442|
|[[:human genes:c:coq2|COQ2]]|0.442|
|[[:human genes:n:ndufb3|NDUFB3]]|0.441|
|[[:human genes:h:higd2a|HIGD2A]]|0.441|
|[[:human genes:c:c10orf2|C10orf2]]|0.44|
|[[:human genes:m:mrpl17|MRPL17]]|0.44|
|[[:human genes:g:gatc|GATC]]|0.439|
|[[:human genes:e:eral1|ERAL1]]|0.439|
|[[:human genes:d:dnlz|DNLZ]]|0.438|
|[[:human genes:p:polg2|POLG2]]|0.438|
|[[:human genes:t:tmem242|TMEM242]]|0.436|
|[[:human genes:a:atp5o|ATP5O]]|0.436|
|[[:human genes:m:mrpl55|MRPL55]]|0.436|
|[[:human genes:n:ndufb5|NDUFB5]]|0.434|
|[[:human genes:c:cox15|COX15]]|0.432|
|[[:human genes:n:ndufv1|NDUFV1]]|0.431|
|[[:human genes:c:cox19|COX19]]|0.43|
|[[:human genes:r:rnmtl1|RNMTL1]]|0.429|
|[[:human genes:n:ndufs2|NDUFS2]]|0.429|
|[[:human genes:m:mrps33|MRPS33]]|0.427|
|[[:human genes:u:uqcr10|UQCR10]]|0.425|
|[[:human genes:o:opa1|OPA1]]|0.425|
|[[:human genes:c:cox5a|COX5A]]|0.421|
|[[:human genes:t:tfam|TFAM]]|0.42|
|[[:human genes:c:c17orf89|C17orf89]]|0.419|
|[[:human genes:m:mrpl37|MRPL37]]|0.419|
|[[:human genes:m:mrpl2|MRPL2]]|0.417|
|[[:human genes:h:hccs|HCCS]]|0.417|
|[[:human genes:p:ppa2|PPA2]]|0.417|
|[[:human genes:d:ddx28|DDX28]]|0.416|
|[[:human genes:m:mrps35|MRPS35]]|0.416|
|[[:human genes:m:malsu1|MALSU1]]|0.416|
|[[:human genes:c:chchd1|CHCHD1]]|0.414|
|[[:human genes:t:timm8b|TIMM8B]]|0.413|
|[[:human genes:m:mrpl51|MRPL51]]|0.412|
|[[:human genes:t:tomm22|TOMM22]]|0.41|
|[[:human genes:w:wars2|WARS2]]|0.41|
|[[:human genes:e:elac2|ELAC2]]|0.409|
|[[:human genes:n:ndufb1|NDUFB1]]|0.409|
|[[:human genes:m:mrpl35|MRPL35]]|0.408|
|[[:human genes:c:chchd4|CHCHD4]]|0.405|
|[[:human genes:m:mettl17|METTL17]]|0.404|
|[[:human genes:c:coa5|COA5]]|0.402|
|[[:human genes:t:tmem261|TMEM261]]|0.401|
|[[:human genes:t:tomm7|TOMM7]]|0.4|
|[[:human genes:a:aasdhppt|AASDHPPT]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 38/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|1/28|
|blood|1/28|
|bone|2/26|
|breast|2/33|
|central nervous system|3/56|
|cervix|1/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|1/16|
|kidney|1/21|
|liver|1/20|
|lung|7/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|2/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|1/22|
|urinary tract|1/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 1188
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.11 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='MRPL20 Expression in NALM6 Cells: 6.11'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>