MRPL20
Gene Information
- Official Symbol: MRPL20
- Official Name: mitochondrial ribosomal protein L20
- Aliases and Previous Symbols: N/A
- Entrez ID: 55052
- UniProt: Q9BYC9
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: N/A
Pfam Domains GO Terms
Pfam Domains
| Ribosomal L20 |
GO Terms
| mitochondrial ribosome |
| ribosomal large subunit assembly |
| rRNA binding |
| mitochondrial large ribosomal subunit |
| ribosome assembly |
| ribosomal large subunit biogenesis |
| mitochondrial translational elongation |
| mitochondrial translational termination |
| translational termination |
| mitochondrial translation |
| translational elongation |
| cellular protein complex disassembly |
| mitochondrial gene expression |
| structural constituent of ribosome |
| ribonucleoprotein complex assembly |
| protein-containing complex disassembly |
| ribonucleoprotein complex subunit organization |
| ribosome biogenesis |
| translation |
| mitochondrial inner membrane |
| cellular component disassembly |
| peptide biosynthetic process |
| ribonucleoprotein complex biogenesis |
| amide biosynthetic process |
| peptide metabolic process |
| organelle assembly |
| cellular amide metabolic process |
| cellular protein-containing complex assembly |
| mitochondrion |
| RNA binding |
| organonitrogen compound biosynthetic process |
| protein-containing complex assembly |
| cellular nitrogen compound biosynthetic process |
| cellular macromolecule biosynthetic process |
| macromolecule biosynthetic process |
| protein-containing complex subunit organization |
| gene expression |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
| Screen | Score |
|---|---|
| Aphidicolin 0.4μM R08 exp440 | 1.72 |
| Chloroquine 32μM R08 exp470 | 1.83 |
| Thimerosal 0.85μM R08 exp529 | 1.85 |
| GSK-J4 1.5μM R08 exp441 | 1.87 |
| iCRT14 30μM R08 exp492 | 1.88 |
| Mubritinib 0.2μM R02 exp65 | 1.9 |
Most Correlated Genes in Chemogenomics
| Gene | Correlation |
|---|---|
| HSD17B10 | 0.635 |
| YARS2 | 0.613 |
| MRPS34 | 0.603 |
| MRPS26 | 0.601 |
| DAP3 | 0.597 |
| MRPS14 | 0.596 |
| RPUSD4 | 0.595 |
| MRPL21 | 0.595 |
| MRPL45 | 0.592 |
| MRPL23 | 0.587 |
| MRP63 | 0.586 |
| VARS2 | 0.586 |
| LARS2 | 0.584 |
| MARS2 | 0.583 |
| NARS2 | 0.583 |
| GFM1 | 0.578 |
| WBSCR16 | 0.573 |
| TARS2 | 0.571 |
| PARS2 | 0.57 |
| COX16 | 0.57 |
| MRPS5 | 0.569 |
| MRPS16 | 0.569 |
| DARS2 | 0.566 |
| SELRC1 | 0.563 |
| EARS2 | 0.562 |
| MRPS6 | 0.552 |
| MRPS21 | 0.551 |
| MRPL53 | 0.549 |
| RARS2 | 0.549 |
| SUPV3L1 | 0.547 |
| FTSJ2 | 0.546 |
| TEFM | 0.54 |
| MRPL3 | 0.539 |
| MRPS2 | 0.537 |
| TUFM | 0.537 |
| BCS1L | 0.536 |
| PNPT1 | 0.535 |
| QRSL1 | 0.533 |
| MRPL47 | 0.53 |
| MRPS9 | 0.529 |
| MTRF1L | 0.525 |
| GTPBP10 | 0.525 |
| GFM2 | 0.524 |
| NDUFA3 | 0.524 |
| NDUFA1 | 0.523 |
| SCO2 | 0.522 |
| HARS2 | 0.522 |
| MRPL39 | 0.515 |
| C12orf65 | 0.51 |
| RBFA | 0.507 |
| PET112 | 0.506 |
| MRPS18A | 0.505 |
| COX7B | 0.503 |
| KIAA0391 | 0.503 |
| MRPS24 | 0.502 |
| MRPS12 | 0.502 |
| ATP5C1 | 0.498 |
| FASTKD5 | 0.496 |
| MRPS7 | 0.493 |
| MRPL15 | 0.493 |
| MRPS11 | 0.491 |
| SARS2 | 0.491 |
| MRPS23 | 0.486 |
| AARS2 | 0.485 |
| NDUFAF7 | 0.484 |
| CARS2 | 0.483 |
| RPUSD3 | 0.482 |
| TRUB2 | 0.48 |
| FARS2 | 0.478 |
| SLC25A26 | 0.478 |
| MRPL18 | 0.477 |
| ATP5B | 0.475 |
| TRIAP1 | 0.474 |
| COA6 | 0.474 |
| MRPS25 | 0.473 |
| MTPAP | 0.471 |
| MRPL36 | 0.471 |
| MTG2 | 0.47 |
| COA3 | 0.468 |
| MRPL44 | 0.468 |
| NDUFB11 | 0.467 |
| MRPS27 | 0.466 |
| NDUFC2 | 0.465 |
| MRPL12 | 0.461 |
| COX11 | 0.46 |
| PET117 | 0.46 |
| RNASEH1 | 0.46 |
| ATP5D | 0.458 |
| UQCRC2 | 0.458 |
| POLG | 0.457 |
| MRPS10 | 0.457 |
| MTG1 | 0.453 |
| MRPL43 | 0.45 |
| AIFM1 | 0.449 |
| ATP5A1 | 0.449 |
| MTERFD1 | 0.447 |
| SSBP1 | 0.446 |
| CLPP | 0.445 |
| MRPL11 | 0.444 |
| POLRMT | 0.444 |
| SSB | 0.444 |
| SLC25A3 | 0.443 |
| MRPS22 | 0.442 |
| COQ2 | 0.442 |
| NDUFB3 | 0.441 |
| HIGD2A | 0.441 |
| C10orf2 | 0.44 |
| MRPL17 | 0.44 |
| GATC | 0.439 |
| ERAL1 | 0.439 |
| DNLZ | 0.438 |
| POLG2 | 0.438 |
| TMEM242 | 0.436 |
| ATP5O | 0.436 |
| MRPL55 | 0.436 |
| NDUFB5 | 0.434 |
| COX15 | 0.432 |
| NDUFV1 | 0.431 |
| COX19 | 0.43 |
| RNMTL1 | 0.429 |
| NDUFS2 | 0.429 |
| MRPS33 | 0.427 |
| UQCR10 | 0.425 |
| OPA1 | 0.425 |
| COX5A | 0.421 |
| TFAM | 0.42 |
| C17orf89 | 0.419 |
| MRPL37 | 0.419 |
| MRPL2 | 0.417 |
| HCCS | 0.417 |
| PPA2 | 0.417 |
| DDX28 | 0.416 |
| MRPS35 | 0.416 |
| MALSU1 | 0.416 |
| CHCHD1 | 0.414 |
| TIMM8B | 0.413 |
| MRPL51 | 0.412 |
| TOMM22 | 0.41 |
| WARS2 | 0.41 |
| ELAC2 | 0.409 |
| NDUFB1 | 0.409 |
| MRPL35 | 0.408 |
| CHCHD4 | 0.405 |
| METTL17 | 0.404 |
| COA5 | 0.402 |
| TMEM261 | 0.401 |
| TOMM7 | 0.4 |
| AASDHPPT | 0.4 |
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 38/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 1/28 |
| blood | 1/28 |
| bone | 2/26 |
| breast | 2/33 |
| central nervous system | 3/56 |
| cervix | 1/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 1/16 |
| kidney | 1/21 |
| liver | 1/20 |
| lung | 7/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 2/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 1/22 |
| urinary tract | 1/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 1188
- Expression level (log2 read counts): 6.11
Expression Distribution
MRPL20 Expression in NALM6 Cells: 6.11
