MRPS11 [The Human Chemical-Genetic Interaction Map Project]

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======= MRPS11 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: MRPS11
  * **<color #00a2e8>Official Name</color>**: mitochondrial ribosomal protein S11
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=64963|64963]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P82912|P82912]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=MRPS11&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20MRPS11|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/611977|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Ribosomal S11|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|small ribosomal subunit rRNA binding|
|ribosomal small subunit assembly|
|mRNA 5-UTR binding|
|mitochondrial small ribosomal subunit|
|maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|
|DNA damage response, detection of DNA damage|
|maturation of SSU-rRNA|
|ribosome assembly|
|ribosomal small subunit biogenesis|
|mitochondrial translational elongation|
|mitochondrial translational termination|
|translational termination|
|mitochondrial translation|
|translational elongation|
|cellular protein complex disassembly|
|mitochondrial gene expression|
|structural constituent of ribosome|
|rRNA processing|
|rRNA metabolic process|
|ribonucleoprotein complex assembly|
|protein-containing complex disassembly|
|ribonucleoprotein complex subunit organization|
|ribosome biogenesis|
|translation|
|ncRNA processing|
|mitochondrial inner membrane|
|cellular component disassembly|
|peptide biosynthetic process|
|ribonucleoprotein complex biogenesis|
|ncRNA metabolic process|
|amide biosynthetic process|
|peptide metabolic process|
|detection of stimulus|
|organelle assembly|
|cellular response to DNA damage stimulus|
|cellular amide metabolic process|
|cellular protein-containing complex assembly|
|RNA processing|
|mitochondrion|
|RNA binding|
|organonitrogen compound biosynthetic process|
|protein-containing complex assembly|
|cellular nitrogen compound biosynthetic process|
|RNA metabolic process|
|cellular response to stress|
|cellular macromolecule biosynthetic process|
|macromolecule biosynthetic process|
|protein-containing complex subunit organization|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp277|Curcumin 6.5μM R06 exp277]]|-2.29|
|[[:results:exp419|Tunicamycin 0.04 to 0.075μM  on day4 R07 exp419]]|-2.18|
|[[:results:exp36|TRAIL 50ng/ml R00 exp36]]|-1.97|
|[[:results:exp481|Ethambutol 25μM R08 exp481]]|-1.92|
|[[:results:exp27|Pimelic-diphenylamide-106 0.5μM R00 exp27]]|-1.9|
|[[:results:exp20|Etoposide 10μM R00 exp20]]|1.7|
|[[:results:exp22|MLN-4924 2μM R00 exp22]]|1.71|
|[[:results:exp451|Atovaquone 15μM R08 exp451]]|1.73|
|[[:results:exp350|Deferoxamine 11μM R07 exp350]]|1.73|
|[[:results:exp527|Tanespimycin 14μM R08 exp527]]|1.81|
|[[:results:exp71|KU-0063794 3.8μM R02 exp71]]|1.85|
|[[:results:exp84|UM0125461 0.74μM R02 exp84]]|1.98|
|[[:results:exp539|42°C R08 exp539]]|2.18|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:m:mrpl21|MRPL21]]|0.582|
|[[:human genes:m:mrps14|MRPS14]]|0.579|
|[[:human genes:g:gfm1|GFM1]]|0.578|
|[[:human genes:h:hsd17b10|HSD17B10]]|0.577|
|[[:human genes:r:rpusd4|RPUSD4]]|0.561|
|[[:human genes:c:c12orf65|C12orf65]]|0.559|
|[[:human genes:y:yars2|YARS2]]|0.554|
|[[:human genes:m:mrps34|MRPS34]]|0.551|
|[[:human genes:m:mrpl15|MRPL15]]|0.548|
|[[:human genes:t:tars2|TARS2]]|0.546|
|[[:human genes:d:dap3|DAP3]]|0.54|
|[[:human genes:s:supv3l1|SUPV3L1]]|0.538|
|[[:human genes:t:tufm|TUFM]]|0.537|
|[[:human genes:m:mrps5|MRPS5]]|0.532|
|[[:human genes:m:mrps6|MRPS6]]|0.529|
|[[:human genes:s:sco2|SCO2]]|0.527|
|[[:human genes:m:mrpl47|MRPL47]]|0.527|
|[[:human genes:r:rbfa|RBFA]]|0.526|
|[[:human genes:m:mrps16|MRPS16]]|0.524|
|[[:human genes:d:dhrsx|DHRSX]]|0.522|
|[[:human genes:m:mrpl23|MRPL23]]|0.521|
|[[:human genes:t:triap1|TRIAP1]]|0.519|
|[[:human genes:m:mrps26|MRPS26]]|0.515|
|[[:human genes:d:dars2|DARS2]]|0.512|
|[[:human genes:v:vars2|VARS2]]|0.512|
|[[:human genes:p:pars2|PARS2]]|0.51|
|[[:human genes:e:elac2|ELAC2]]|0.507|
|[[:human genes:a:atp5a1|ATP5A1]]|0.505|
|[[:human genes:s:selrc1|SELRC1]]|0.503|
|[[:human genes:n:ndufaf7|NDUFAF7]]|0.502|
|[[:human genes:n:ndufa3|NDUFA3]]|0.501|
|[[:human genes:p:polg|POLG]]|0.499|
|[[:human genes:m:mrp63|MRP63]]|0.497|
|[[:human genes:m:mrps18a|MRPS18A]]|0.496|
|[[:human genes:c:cox16|COX16]]|0.494|
|[[:human genes:m:mrpl20|MRPL20]]|0.491|
|[[:human genes:v:vezt|VEZT]]|0.488|
|[[:human genes:b:bcs1l|BCS1L]]|0.486|
|[[:human genes:r:rnaseh1|RNASEH1]]|0.483|
|[[:human genes:m:mrps21|MRPS21]]|0.483|
|[[:human genes:g:gtpbp10|GTPBP10]]|0.482|
|[[:human genes:n:ndufb11|NDUFB11]]|0.48|
|[[:human genes:n:nars2|NARS2]]|0.48|
|[[:human genes:w:wbscr16|WBSCR16]]|0.478|
|[[:human genes:t:tomm20|TOMM20]]|0.476|
|[[:human genes:q:qrsl1|QRSL1]]|0.473|
|[[:human genes:f:fastkd5|FASTKD5]]|0.471|
|[[:human genes:m:mrpl53|MRPL53]]|0.471|
|[[:human genes:p:pnpt1|PNPT1]]|0.468|
|[[:human genes:k:kiaa0391|KIAA0391]]|0.467|
|[[:human genes:c:coq2|COQ2]]|0.467|
|[[:human genes:c:cox15|COX15]]|0.466|
|[[:human genes:s:slc25a26|SLC25A26]]|0.464|
|[[:human genes:r:rars2|RARS2]]|0.463|
|[[:human genes:m:mrps23|MRPS23]]|0.463|
|[[:human genes:t:tefm|TEFM]]|0.463|
|[[:human genes:g:gfm2|GFM2]]|0.462|
|[[:human genes:c:c17orf89|C17orf89]]|0.461|
|[[:human genes:c:chchd4|CHCHD4]]|0.461|
|[[:human genes:e:ears2|EARS2]]|0.46|
|[[:human genes:l:lars2|LARS2]]|0.46|
|[[:human genes:n:ndufb5|NDUFB5]]|0.46|
|[[:human genes:m:mrpl45|MRPL45]]|0.459|
|[[:human genes:m:mrpl39|MRPL39]]|0.459|
|[[:human genes:m:mrps33|MRPS33]]|0.457|
|[[:human genes:s:sars2|SARS2]]|0.456|
|[[:human genes:n:ndufb6|NDUFB6]]|0.455|
|[[:human genes:z:zrsr2|ZRSR2]]|0.455|
|[[:human genes:m:mrps25|MRPS25]]|0.454|
|[[:human genes:m:mrps2|MRPS2]]|0.454|
|[[:human genes:g:gatc|GATC]]|0.454|
|[[:human genes:a:atp5d|ATP5D]]|0.451|
|[[:human genes:u:uqcrc2|UQCRC2]]|0.451|
|[[:human genes:m:mettl17|METTL17]]|0.45|
|[[:human genes:a:atxn10|ATXN10]]|0.45|
|[[:human genes:p:polrmt|POLRMT]]|0.448|
|[[:human genes:c:c10orf2|C10orf2]]|0.447|
|[[:human genes:m:mars2|MARS2]]|0.444|
|[[:human genes:t:tomm22|TOMM22]]|0.443|
|[[:human genes:m:mtg1|MTG1]]|0.442|
|[[:human genes:r:rpe|RPE]]|0.44|
|[[:human genes:m:mtrf1l|MTRF1L]]|0.44|
|[[:human genes:f:fh|FH]]|0.438|
|[[:human genes:d:dpagt1|DPAGT1]]|0.438|
|[[:human genes:m:mrpl55|MRPL55]]|0.438|
|[[:human genes:f:fars2|FARS2]]|0.437|
|[[:human genes:m:mrps17|MRPS17]]|0.434|
|[[:human genes:h:hccs|HCCS]]|0.434|
|[[:human genes:m:mrpl42|MRPL42]]|0.434|
|[[:human genes:n:ndufb3|NDUFB3]]|0.434|
|[[:human genes:l:lsm10|LSM10]]|0.432|
|[[:human genes:t:taz|TAZ]]|0.431|
|[[:human genes:a:atp5b|ATP5B]]|0.43|
|[[:human genes:m:mrpl44|MRPL44]]|0.43|
|[[:human genes:h:higd2a|HIGD2A]]|0.429|
|[[:human genes:n:ndufa2|NDUFA2]]|0.429|
|[[:human genes:t:timm8b|TIMM8B]]|0.428|
|[[:human genes:c:cox17|COX17]]|0.428|
|[[:human genes:r:rpia|RPIA]]|0.427|
|[[:human genes:f:ftsj2|FTSJ2]]|0.427|
|[[:human genes:m:mrps24|MRPS24]]|0.426|
|[[:human genes:p:ppcs|PPCS]]|0.426|
|[[:human genes:m:mrps22|MRPS22]]|0.425|
|[[:human genes:r:rbmx2|RBMX2]]|0.425|
|[[:human genes:c:coq3|COQ3]]|0.424|
|[[:human genes:a:atp5sl|ATP5SL]]|0.424|
|[[:human genes:n:ndufaf4|NDUFAF4]]|0.424|
|[[:human genes:s:sec62|SEC62]]|0.423|
|[[:human genes:c:cox7b|COX7B]]|0.423|
|[[:human genes:m:mrps9|MRPS9]]|0.419|
|[[:human genes:r:rpusd3|RPUSD3]]|0.419|
|[[:human genes:a:aasdhppt|AASDHPPT]]|0.419|
|[[:human genes:c:cox6c|COX6C]]|0.417|
|[[:human genes:p:pmm2|PMM2]]|0.416|
|[[:human genes:c:coa6|COA6]]|0.416|
|[[:human genes:p:pgm3|PGM3]]|0.415|
|[[:human genes:t:tmem242|TMEM242]]|0.415|
|[[:human genes:i:iba57|IBA57]]|0.412|
|[[:human genes:m:mterfd2|MTERFD2]]|0.412|
|[[:human genes:d:dhx30|DHX30]]|0.412|
|[[:human genes:m:mrpl34|MRPL34]]|0.411|
|[[:human genes:a:aifm1|AIFM1]]|0.411|
|[[:human genes:m:mrpl41|MRPL41]]|0.408|
|[[:human genes:m:mrpl22|MRPL22]]|0.408|
|[[:human genes:m:minos1|MINOS1]]|0.407|
|[[:human genes:a:atp5c1|ATP5C1]]|0.407|
|[[:human genes:n:ndufs2|NDUFS2]]|0.406|
|[[:human genes:p:polg2|POLG2]]|0.403|
|[[:human genes:u:uqcc2|UQCC2]]|0.402|
|[[:human genes:a:alg1|ALG1]]|0.401|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 290/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|12/28|
|blood|8/28|
|bone|8/26|
|breast|16/33|
|central nervous system|15/56|
|cervix|2/4|
|colorectal|9/17|
|esophagus|10/13|
|fibroblast|0/1|
|gastric|7/16|
|kidney|5/21|
|liver|10/20|
|lung|30/75|
|lymphocyte|7/16|
|ovary|5/26|
|pancreas|6/24|
|peripheral nervous system|6/16|
|plasma cell|5/15|
|prostate|0/1|
|skin|9/24|
|soft tissue|3/9|
|thyroid|0/2|
|upper aerodigestive|11/22|
|urinary tract|14/29|
|uterus|2/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 2960
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.31 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='MRPS11 Expression in NALM6 Cells: 5.31'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>