MRPS11
Gene Information
- Official Symbol: MRPS11
- Official Name: mitochondrial ribosomal protein S11
- Aliases and Previous Symbols: N/A
- Entrez ID: 64963
- UniProt: P82912
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: N/A
Pfam Domains GO Terms
Pfam Domains
| Ribosomal S11 |
GO Terms
| small ribosomal subunit rRNA binding |
| ribosomal small subunit assembly |
| mRNA 5-UTR binding |
| mitochondrial small ribosomal subunit |
| maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) |
| DNA damage response, detection of DNA damage |
| maturation of SSU-rRNA |
| ribosome assembly |
| ribosomal small subunit biogenesis |
| mitochondrial translational elongation |
| mitochondrial translational termination |
| translational termination |
| mitochondrial translation |
| translational elongation |
| cellular protein complex disassembly |
| mitochondrial gene expression |
| structural constituent of ribosome |
| rRNA processing |
| rRNA metabolic process |
| ribonucleoprotein complex assembly |
| protein-containing complex disassembly |
| ribonucleoprotein complex subunit organization |
| ribosome biogenesis |
| translation |
| ncRNA processing |
| mitochondrial inner membrane |
| cellular component disassembly |
| peptide biosynthetic process |
| ribonucleoprotein complex biogenesis |
| ncRNA metabolic process |
| amide biosynthetic process |
| peptide metabolic process |
| detection of stimulus |
| organelle assembly |
| cellular response to DNA damage stimulus |
| cellular amide metabolic process |
| cellular protein-containing complex assembly |
| RNA processing |
| mitochondrion |
| RNA binding |
| organonitrogen compound biosynthetic process |
| protein-containing complex assembly |
| cellular nitrogen compound biosynthetic process |
| RNA metabolic process |
| cellular response to stress |
| cellular macromolecule biosynthetic process |
| macromolecule biosynthetic process |
| protein-containing complex subunit organization |
| gene expression |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
Most Correlated Genes in Chemogenomics
| Gene | Correlation |
|---|---|
| MRPL21 | 0.582 |
| MRPS14 | 0.579 |
| GFM1 | 0.578 |
| HSD17B10 | 0.577 |
| RPUSD4 | 0.561 |
| C12orf65 | 0.559 |
| YARS2 | 0.554 |
| MRPS34 | 0.551 |
| MRPL15 | 0.548 |
| TARS2 | 0.546 |
| DAP3 | 0.54 |
| SUPV3L1 | 0.538 |
| TUFM | 0.537 |
| MRPS5 | 0.532 |
| MRPS6 | 0.529 |
| SCO2 | 0.527 |
| MRPL47 | 0.527 |
| RBFA | 0.526 |
| MRPS16 | 0.524 |
| DHRSX | 0.522 |
| MRPL23 | 0.521 |
| TRIAP1 | 0.519 |
| MRPS26 | 0.515 |
| DARS2 | 0.512 |
| VARS2 | 0.512 |
| PARS2 | 0.51 |
| ELAC2 | 0.507 |
| ATP5A1 | 0.505 |
| SELRC1 | 0.503 |
| NDUFAF7 | 0.502 |
| NDUFA3 | 0.501 |
| POLG | 0.499 |
| MRP63 | 0.497 |
| MRPS18A | 0.496 |
| COX16 | 0.494 |
| MRPL20 | 0.491 |
| VEZT | 0.488 |
| BCS1L | 0.486 |
| RNASEH1 | 0.483 |
| MRPS21 | 0.483 |
| GTPBP10 | 0.482 |
| NDUFB11 | 0.48 |
| NARS2 | 0.48 |
| WBSCR16 | 0.478 |
| TOMM20 | 0.476 |
| QRSL1 | 0.473 |
| FASTKD5 | 0.471 |
| MRPL53 | 0.471 |
| PNPT1 | 0.468 |
| KIAA0391 | 0.467 |
| COQ2 | 0.467 |
| COX15 | 0.466 |
| SLC25A26 | 0.464 |
| RARS2 | 0.463 |
| MRPS23 | 0.463 |
| TEFM | 0.463 |
| GFM2 | 0.462 |
| C17orf89 | 0.461 |
| CHCHD4 | 0.461 |
| EARS2 | 0.46 |
| LARS2 | 0.46 |
| NDUFB5 | 0.46 |
| MRPL45 | 0.459 |
| MRPL39 | 0.459 |
| MRPS33 | 0.457 |
| SARS2 | 0.456 |
| NDUFB6 | 0.455 |
| ZRSR2 | 0.455 |
| MRPS25 | 0.454 |
| MRPS2 | 0.454 |
| GATC | 0.454 |
| ATP5D | 0.451 |
| UQCRC2 | 0.451 |
| METTL17 | 0.45 |
| ATXN10 | 0.45 |
| POLRMT | 0.448 |
| C10orf2 | 0.447 |
| MARS2 | 0.444 |
| TOMM22 | 0.443 |
| MTG1 | 0.442 |
| RPE | 0.44 |
| MTRF1L | 0.44 |
| FH | 0.438 |
| DPAGT1 | 0.438 |
| MRPL55 | 0.438 |
| FARS2 | 0.437 |
| MRPS17 | 0.434 |
| HCCS | 0.434 |
| MRPL42 | 0.434 |
| NDUFB3 | 0.434 |
| LSM10 | 0.432 |
| TAZ | 0.431 |
| ATP5B | 0.43 |
| MRPL44 | 0.43 |
| HIGD2A | 0.429 |
| NDUFA2 | 0.429 |
| TIMM8B | 0.428 |
| COX17 | 0.428 |
| RPIA | 0.427 |
| FTSJ2 | 0.427 |
| MRPS24 | 0.426 |
| PPCS | 0.426 |
| MRPS22 | 0.425 |
| RBMX2 | 0.425 |
| COQ3 | 0.424 |
| ATP5SL | 0.424 |
| NDUFAF4 | 0.424 |
| SEC62 | 0.423 |
| COX7B | 0.423 |
| MRPS9 | 0.419 |
| RPUSD3 | 0.419 |
| AASDHPPT | 0.419 |
| COX6C | 0.417 |
| PMM2 | 0.416 |
| COA6 | 0.416 |
| PGM3 | 0.415 |
| TMEM242 | 0.415 |
| IBA57 | 0.412 |
| MTERFD2 | 0.412 |
| DHX30 | 0.412 |
| MRPL34 | 0.411 |
| AIFM1 | 0.411 |
| MRPL41 | 0.408 |
| MRPL22 | 0.408 |
| MINOS1 | 0.407 |
| ATP5C1 | 0.407 |
| NDUFS2 | 0.406 |
| POLG2 | 0.403 |
| UQCC2 | 0.402 |
| ALG1 | 0.401 |
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 290/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 12/28 |
| blood | 8/28 |
| bone | 8/26 |
| breast | 16/33 |
| central nervous system | 15/56 |
| cervix | 2/4 |
| colorectal | 9/17 |
| esophagus | 10/13 |
| fibroblast | 0/1 |
| gastric | 7/16 |
| kidney | 5/21 |
| liver | 10/20 |
| lung | 30/75 |
| lymphocyte | 7/16 |
| ovary | 5/26 |
| pancreas | 6/24 |
| peripheral nervous system | 6/16 |
| plasma cell | 5/15 |
| prostate | 0/1 |
| skin | 9/24 |
| soft tissue | 3/9 |
| thyroid | 0/2 |
| upper aerodigestive | 11/22 |
| urinary tract | 14/29 |
| uterus | 2/5 |
Essentiality in NALM6
- Essentiality Rank: 2960
- Expression level (log2 read counts): 5.31
Expression Distribution
MRPS11 Expression in NALM6 Cells: 5.31
