MRPS27 [The Human Chemical-Genetic Interaction Map Project]

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======= MRPS27 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: MRPS27
  * **<color #00a2e8>Official Name</color>**: mitochondrial ribosomal protein S27
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=23107|23107]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q92552|Q92552]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=MRPS27&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20MRPS27|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/611989|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  RNA-binding component of the mitochondrial small ribosomal subunit (mt-SSU) that plays a role in mitochondrial protein synthesis (PubMed:22841715). Stimulates mitochondrial mRNA translation of subunit components of the mitochondrial electron transport chain (PubMed:22841715). Binds to the mitochondrial 12S rRNA (12S mt-rRNA) and tRNA(Glu) (PubMed:22841715). Involved also in positive regulation of cell proliferation and tumor cell growth (PubMed:28714366). {ECO:0000269|PubMed:22841715, ECO:0000269|PubMed:28714366}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|MRP-S27|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|mitochondrial ribosome binding|
|positive regulation of mitochondrial translation|
|regulation of mitochondrial translation|
|regulation of mitochondrial gene expression|
|mitochondrial small ribosomal subunit|
|rRNA binding|
|tRNA binding|
|mitochondrial translational termination|
|mitochondrial translational elongation|
|translational termination|
|mitochondrial translation|
|translational elongation|
|positive regulation of translation|
|cellular protein complex disassembly|
|mitochondrial gene expression|
|positive regulation of cellular amide metabolic process|
|protein-containing complex disassembly|
|regulation of translation|
|translation|
|mitochondrial inner membrane|
|cellular component disassembly|
|regulation of cellular amide metabolic process|
|peptide biosynthetic process|
|posttranscriptional regulation of gene expression|
|amide biosynthetic process|
|peptide metabolic process|
|cell population proliferation|
|cellular amide metabolic process|
|mitochondrion|
|organonitrogen compound biosynthetic process|
|positive regulation of cellular protein metabolic process|
|cellular nitrogen compound biosynthetic process|
|positive regulation of protein metabolic process|
|cellular macromolecule biosynthetic process|
|macromolecule biosynthetic process|
|protein-containing complex subunit organization|
|positive regulation of macromolecule biosynthetic process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp452|Azithromycin 100μM R08 exp452]]|1.73|
|[[:results:exp430|Rifampicin 30μM R08 exp430]]|1.75|
|[[:results:exp350|Deferoxamine 11μM R07 exp350]]|1.9|
|[[:results:exp66|BI-D1870 3.15μM R02 exp66]]|1.93|
|[[:results:exp48|Mubritinib 0.2μM R01 exp48]]|1.95|
|[[:results:exp212|Phenformin 20μM R05 exp212]]|2.03|
|[[:results:exp329|Hydroxyurea 100μM R07 exp329]]|2.32|
|[[:results:exp65|Mubritinib 0.2μM R02 exp65]]|2.34|
|[[:results:exp25|Oligomycin-A 2μM R00 exp25]]|2.35|
|[[:results:exp84|UM0125461 0.74μM R02 exp84]]|2.49|
|[[:results:exp529|Thimerosal 0.85μM R08 exp529]]|2.73|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:p:pet117|PET117]]|0.586|
|[[:human genes:m:mettl17|METTL17]]|0.586|
|[[:human genes:c:coa3|COA3]]|0.585|
|[[:human genes:p:pet112|PET112]]|0.572|
|[[:human genes:n:nars2|NARS2]]|0.559|
|[[:human genes:p:polrmt|POLRMT]]|0.558|
|[[:human genes:m:mars2|MARS2]]|0.552|
|[[:human genes:m:mrpl45|MRPL45]]|0.549|
|[[:human genes:c:cars2|CARS2]]|0.546|
|[[:human genes:n:ndufb11|NDUFB11]]|0.545|
|[[:human genes:q:qrsl1|QRSL1]]|0.538|
|[[:human genes:t:tars2|TARS2]]|0.525|
|[[:human genes:a:acad9|ACAD9]]|0.523|
|[[:human genes:e:ears2|EARS2]]|0.522|
|[[:human genes:f:ftsj2|FTSJ2]]|0.52|
|[[:human genes:m:mrps25|MRPS25]]|0.517|
|[[:human genes:m:mrpl17|MRPL17]]|0.515|
|[[:human genes:m:mterfd1|MTERFD1]]|0.515|
|[[:human genes:h:hsd17b10|HSD17B10]]|0.514|
|[[:human genes:m:mto1|MTO1]]|0.514|
|[[:human genes:v:vars2|VARS2]]|0.514|
|[[:human genes:a:aars2|AARS2]]|0.513|
|[[:human genes:m:mrps21|MRPS21]]|0.513|
|[[:human genes:r:rpusd3|RPUSD3]]|0.512|
|[[:human genes:l:lars2|LARS2]]|0.511|
|[[:human genes:p:ptcd3|PTCD3]]|0.51|
|[[:human genes:f:fastkd2|FASTKD2]]|0.508|
|[[:human genes:m:malsu1|MALSU1]]|0.507|
|[[:human genes:m:mrps12|MRPS12]]|0.505|
|[[:human genes:m:mrps34|MRPS34]]|0.501|
|[[:human genes:m:mrpl3|MRPL3]]|0.501|
|[[:human genes:g:grsf1|GRSF1]]|0.501|
|[[:human genes:r:rbfa|RBFA]]|0.499|
|[[:human genes:s:selrc1|SELRC1]]|0.498|
|[[:human genes:n:ndufaf5|NDUFAF5]]|0.495|
|[[:human genes:n:ndufa8|NDUFA8]]|0.493|
|[[:human genes:d:dap3|DAP3]]|0.492|
|[[:human genes:p:pars2|PARS2]]|0.49|
|[[:human genes:t:tfb1m|TFB1M]]|0.489|
|[[:human genes:g:gfm1|GFM1]]|0.488|
|[[:human genes:n:ndufa1|NDUFA1]]|0.488|
|[[:human genes:d:ddx28|DDX28]]|0.487|
|[[:human genes:c:cox15|COX15]]|0.486|
|[[:human genes:y:yars2|YARS2]]|0.486|
|[[:human genes:n:ndufaf7|NDUFAF7]]|0.485|
|[[:human genes:n:ndufs2|NDUFS2]]|0.484|
|[[:human genes:m:mrps35|MRPS35]]|0.482|
|[[:human genes:c:coa6|COA6]]|0.48|
|[[:human genes:w:wbscr16|WBSCR16]]|0.479|
|[[:human genes:m:mrpl53|MRPL53]]|0.477|
|[[:human genes:m:mtg1|MTG1]]|0.475|
|[[:human genes:m:mtif2|MTIF2]]|0.474|
|[[:human genes:m:mrp63|MRP63]]|0.474|
|[[:human genes:m:mrps6|MRPS6]]|0.473|
|[[:human genes:r:rars2|RARS2]]|0.47|
|[[:human genes:l:lrpprc|LRPPRC]]|0.469|
|[[:human genes:m:mrpl20|MRPL20]]|0.466|
|[[:human genes:m:mrpl9|MRPL9]]|0.463|
|[[:human genes:f:fars2|FARS2]]|0.461|
|[[:human genes:n:ndufs5|NDUFS5]]|0.46|
|[[:human genes:m:mrpl43|MRPL43]]|0.459|
|[[:human genes:w:wars2|WARS2]]|0.458|
|[[:human genes:n:nsun4|NSUN4]]|0.457|
|[[:human genes:x:xpnpep3|XPNPEP3]]|0.457|
|[[:human genes:m:mtrf1l|MTRF1L]]|0.456|
|[[:human genes:e:eral1|ERAL1]]|0.456|
|[[:human genes:n:ndufa3|NDUFA3]]|0.455|
|[[:human genes:s:sco2|SCO2]]|0.455|
|[[:human genes:c:cox11|COX11]]|0.454|
|[[:human genes:n:ndufb9|NDUFB9]]|0.452|
|[[:human genes:s:sco1|SCO1]]|0.45|
|[[:human genes:m:mrpl50|MRPL50]]|0.45|
|[[:human genes:n:ndufa2|NDUFA2]]|0.447|
|[[:human genes:d:dars2|DARS2]]|0.447|
|[[:human genes:g:gtpbp6|GTPBP6]]|0.447|
|[[:human genes:m:mrpl37|MRPL37]]|0.447|
|[[:human genes:m:mrpl21|MRPL21]]|0.446|
|[[:human genes:r:rpusd4|RPUSD4]]|0.446|
|[[:human genes:m:mrps16|MRPS16]]|0.446|
|[[:human genes:m:mrps26|MRPS26]]|0.445|
|[[:human genes:c:c12orf65|C12orf65]]|0.445|
|[[:human genes:p:polg2|POLG2]]|0.445|
|[[:human genes:r:rnmtl1|RNMTL1]]|0.444|
|[[:human genes:m:mrpl4|MRPL4]]|0.444|
|[[:human genes:c:chchd1|CHCHD1]]|0.443|
|[[:human genes:p:pde12|PDE12]]|0.443|
|[[:human genes:p:polg|POLG]]|0.442|
|[[:human genes:m:mrpl23|MRPL23]]|0.441|
|[[:human genes:m:mterfd2|MTERFD2]]|0.439|
|[[:human genes:n:ndufs8|NDUFS8]]|0.438|
|[[:human genes:s:slc25a3|SLC25A3]]|0.437|
|[[:human genes:t:trub2|TRUB2]]|0.436|
|[[:human genes:n:ndufb4|NDUFB4]]|0.433|
|[[:human genes:r:rmnd1|RMND1]]|0.433|
|[[:human genes:s:slc25a51|SLC25A51]]|0.431|
|[[:human genes:r:rtn4ip1|RTN4IP1]]|0.43|
|[[:human genes:h:hars2|HARS2]]|0.429|
|[[:human genes:m:mrpl49|MRPL49]]|0.425|
|[[:human genes:m:mrpl28|MRPL28]]|0.424|
|[[:human genes:n:ndufa11|NDUFA11]]|0.424|
|[[:human genes:m:mcat|MCAT]]|0.424|
|[[:human genes:t:timmdc1|TIMMDC1]]|0.423|
|[[:human genes:i:iba57|IBA57]]|0.422|
|[[:human genes:a:aifm1|AIFM1]]|0.421|
|[[:human genes:h:hmgxb3|HMGXB3]]|0.42|
|[[:human genes:m:mtg2|MTG2]]|0.419|
|[[:human genes:m:mrpl44|MRPL44]]|0.419|
|[[:human genes:n:ndufa13|NDUFA13]]|0.419|
|[[:human genes:m:mrpl11|MRPL11]]|0.418|
|[[:human genes:g:gtpbp8|GTPBP8]]|0.418|
|[[:human genes:c:clpp|CLPP]]|0.416|
|[[:human genes:m:mrps18b|MRPS18B]]|0.416|
|[[:human genes:f:fastkd5|FASTKD5]]|0.415|
|[[:human genes:m:mrps7|MRPS7]]|0.415|
|[[:human genes:m:mrps14|MRPS14]]|0.414|
|[[:human genes:n:ndufaf3|NDUFAF3]]|0.413|
|[[:human genes:t:trit1|TRIT1]]|0.412|
|[[:human genes:m:mrpl51|MRPL51]]|0.411|
|[[:human genes:m:mrps10|MRPS10]]|0.411|
|[[:human genes:n:ndufb6|NDUFB6]]|0.411|
|[[:human genes:m:mrpl42|MRPL42]]|0.41|
|[[:human genes:c:cox20|COX20]]|0.408|
|[[:human genes:m:mrpl2|MRPL2]]|0.408|
|[[:human genes:n:nubpl|NUBPL]]|0.407|
|[[:human genes:c:coq2|COQ2]]|0.407|
|[[:human genes:s:slc31a1|SLC31A1]]|0.405|
|[[:human genes:n:ndufc2|NDUFC2]]|0.404|
|[[:human genes:n:ndufv1|NDUFV1]]|0.404|
|[[:human genes:n:nsun3|NSUN3]]|0.404|
|[[:human genes:m:mrpl47|MRPL47]]|0.404|
|[[:human genes:m:mrps24|MRPS24]]|0.404|
|[[:human genes:m:mrpl12|MRPL12]]|0.403|
|[[:human genes:m:mrpl1|MRPL1]]|0.402|
|[[:human genes:n:ndufaf6|NDUFAF6]]|0.4|
|[[:human genes:m:mrps5|MRPS5]]|0.4|
|[[:human genes:p:pnpt1|PNPT1]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 27/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|2/28|
|blood|1/28|
|bone|0/26|
|breast|2/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|1/13|
|fibroblast|0/1|
|gastric|2/16|
|kidney|1/21|
|liver|0/20|
|lung|5/75|
|lymphocyte|2/16|
|ovary|0/26|
|pancreas|1/24|
|peripheral nervous system|0/16|
|plasma cell|1/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|2/9|
|thyroid|0/2|
|upper aerodigestive|2/22|
|urinary tract|1/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 429
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 7.45 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='MRPS27 Expression in NALM6 Cells: 7.45'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>