MRPS27

Entrez Summary: N/A
UniProt Summary: RNA-binding component of the mitochondrial small ribosomal subunit (mt-SSU) that plays a role in mitochondrial protein synthesis (PubMed:22841715). Stimulates mitochondrial mRNA translation of subunit components of the mitochondrial electron transport chain (PubMed:22841715). Binds to the mitochondrial 12S rRNA (12S mt-rRNA) and tRNA(Glu) (PubMed:22841715). Involved also in positive regulation of cell proliferation and tumor cell growth (PubMed:28714366). {ECO:0000269|PubMed:22841715, ECO:0000269|PubMed:28714366}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 27/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	2/28
blood	1/28
bone	0/26
breast	2/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	1/13
fibroblast	0/1
gastric	2/16
kidney	1/21
liver	0/20
lung	5/75
lymphocyte	2/16
ovary	0/26
pancreas	1/24
peripheral nervous system	0/16
plasma cell	1/15
prostate	0/1
skin	0/24
soft tissue	2/9
thyroid	0/2
upper aerodigestive	2/22
urinary tract	1/29
uterus	0/5

Expression Distribution

mitochondrial ribosome binding
positive regulation of mitochondrial translation
regulation of mitochondrial translation
regulation of mitochondrial gene expression
mitochondrial small ribosomal subunit
rRNA binding
tRNA binding
mitochondrial translational termination
mitochondrial translational elongation
translational termination
mitochondrial translation
translational elongation
positive regulation of translation
cellular protein complex disassembly
mitochondrial gene expression
positive regulation of cellular amide metabolic process
protein-containing complex disassembly
regulation of translation
translation
mitochondrial inner membrane
cellular component disassembly
regulation of cellular amide metabolic process
peptide biosynthetic process
posttranscriptional regulation of gene expression
amide biosynthetic process
peptide metabolic process
cell population proliferation
cellular amide metabolic process
mitochondrion
organonitrogen compound biosynthetic process
positive regulation of cellular protein metabolic process
cellular nitrogen compound biosynthetic process
positive regulation of protein metabolic process
cellular macromolecule biosynthetic process
macromolecule biosynthetic process
protein-containing complex subunit organization
positive regulation of macromolecule biosynthetic process
positive regulation of cellular biosynthetic process
positive regulation of gene expression
gene expression